{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:08:55Z","timestamp":1785600535304,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T00:00:00Z","timestamp":1148515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjectives<\/jats:sc>:<\/jats:bold><jats:bold>To evaluate the effect of short duration 1 per cent clotrimazole flush when combined with 1 per cent clotrimazole cream instilled into the frontal sinuses for the treatment of nasal aspergillosis in 14 dogs.<\/jats:bold><\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>:<\/jats:bold><jats:bold>Fourteen dogs with clinical, radiological, serological and rhinoscopic findings consistent with nasal aspergillosis were treated by frontal sinus trephination and a short, five\u2010minute flushing of 1 per cent topical clotrimazole solution followed by a 1 per cent clotrimazole cream instilled as a depot agent.<\/jats:bold><\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>:<\/jats:bold><jats:bold>Twelve of the 14 dogs (86 per cent) responded well to treatment and either had no clinical signs after treatment or had signs consistent with mild rhinitis during a minimum follow\u2010up period of six months. Only one dog required multiple treatments. Treatment was well tolerated by all patients, with minimal complications.<\/jats:bold><\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc>S<jats:sc>ignificance<\/jats:sc>:<\/jats:bold><jats:bold>This treatment compares favourably to previously published data using one\u2010hour topical clotrimazole or enilconazole flushing treatment protocols. The treatment technique significantly reduced treatment time under anaesthesia.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2006.00017.x","type":"journal-article","created":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T13:01:02Z","timestamp":1148562062000},"page":"312-315","source":"Crossref","is-referenced-by-count":40,"title":["Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis"],"prefix":"10.1111","volume":"47","author":[{"given":"T. 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