{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:55:42Z","timestamp":1769097342896,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T00:00:00Z","timestamp":1159401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Moxidectin is a macrocyclic lactone related to ivermectin used in horses and dogs for endoparasite treatment and prophylaxis. The clinical and neurological presentation of moxidectin toxicity in two dogs following inadvertent poisoning with a moxidectin\u2010containing equine de\u2010worming medication is reported here. In both the dogs, the predominant clinical signs were generalised tremors and ataxia. Moxidectin exerts its neurotoxic effects in mammals by potentiating the effect of \u03b3\u2010aminobutyric acid and, consistent with this, both the dogs demonstrated a poor response to treatment with diazepam. It would be more appropriate to avoid \u03b3\u2010aminobutyric acid agonists, such as benzodiazepines and barbiturates, in dogs with moxidectin toxicity and consider using anaesthetic agents with a different mode of action, such as propofol. The prognosis in dogs accidentally exposed to moxidectin\u2010containing equine de\u2010worming medication appears to be excellent if the cause of the neurotoxicity is correctly identified and the case is appropriately managed.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2006.00081.x","type":"journal-article","created":{"date-parts":[[2006,9,28]],"date-time":"2006-09-28T08:09:35Z","timestamp":1159430975000},"page":"620-624","source":"Crossref","is-referenced-by-count":28,"title":["Clinical presentation and management of moxidectin toxicity in two dogs"],"prefix":"10.1111","volume":"47","author":[{"given":"N. J.","family":"Snowden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. V.","family":"Helyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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