{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:48:17Z","timestamp":1769554097713,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:00:00Z","timestamp":1152230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjectives<\/jats:sc>: <\/jats:bold>  <jats:bold>To record a previously unreported congenital and hereditary condition affecting the eyes and skin in the cavalier King Charles spaniel.<\/jats:bold> <\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>: <\/jats:bold>  <jats:bold>Nineteen cases (13 litters) were investigated, with particular reference to eye and skin clinical signs. In addition, five generation pedigrees were obtained and studied from all cases with the exception of one.<\/jats:bold> <\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>: <\/jats:bold>  <jats:bold>The eye signs were due to keratoconjunctivitis sicca, a common ocular disease in the dog, but rarely of congenital origin. The skin signs were of an ichthyosiform dermatosis; ichthyosis being a rare skin disease in the dog. In human beings, ichthyosis is a similar disease, mainly inherited and with a neonatal onset, and sometimes accompanied by other developmental defects. In the cavalier King Charles spaniel, the coat abnormality was noted at birth by the breeders as a \u2018curly coat\u2019, with deterioration of the skin signs as the animal became adult.<\/jats:bold> <\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc> S<jats:sc>ignificance<\/jats:sc>: <\/jats:bold>  <jats:bold>These two conditions occurring together in this breed is well recognised by some breeders but rarely by the veterinary profession. Successful treatment is not possible, although some improvement, particularly of the keratoconjunctivitis sicca, can be obtained. The probable hereditary nature of the condition is an important factor for control.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1748-5827.2006.00107.x","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T18:13:58Z","timestamp":1152296038000},"page":"524-528","source":"Crossref","is-referenced-by-count":17,"title":["Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel"],"prefix":"10.1111","volume":"47","author":[{"given":"K. C.","family":"Barnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1994.tb00023.x"},{"key":"e_1_2_6_3_1","first-page":"1483","volume-title":"Textbook of Dermatology","author":"Griffiths W. A. 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