{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:21:58Z","timestamp":1761578518156},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T00:00:00Z","timestamp":1156982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjectives<\/jats:sc>: <\/jats:bold>  <jats:bold>Peripheral parenteral nutrition is an option for short\u2010term nutritional support in dogs which cannot be supported with enteral nutrition. The objective of this study was to examine the use of a three\u2010in\u2010one, 840 mOsmol\/l peripheral parenteral nutrition product containing amino acids, lipids and glucose in separate compartments in dogs.<\/jats:bold> <\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>: <\/jats:bold>  <jats:bold>Nine dogs were administered the three\u2010in\u2010one product, and two dogs were administered the amino acid part of the product, via a peripheral vein. Dogs were monitored for mechanical and metabolic complications.<\/jats:bold> <\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>: <\/jats:bold>  <jats:bold>Mechanical complications (apparent thrombus or thrombophlebitis) caused failure of infusion at a median of 36 hours. None of the dogs appeared to develop catheter\u2010related sepsis. Using a 10\u2010hour infusion period appeared to decrease the incidence of line failure. Mild and clinically non\u2010significant hyperglycaemia was the only metabolic complication. In four of the dogs, serum folate, cobalamin and homocysteine concentrations were determined before and after peripheral parenteral nutrition administration. Oral and parenteral administration of methionine has been previously associated with lowered serum folate concentrations. Low serum folates and the subsequent hyperhomocysteinaemia have been associated with venous endothelial damage and venous thrombus in other species. Serum cobalamin also affects homocysteine metabolism. Median serum folate, cobalamin and homocysteine concentrations were not affected by the short\u2010term administration of this three\u2010in\u2010one product.<\/jats:bold> <\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc> S<jats:sc>ignificance<\/jats:sc>: <\/jats:bold>  <jats:bold>Using the product for 24 hours\/day may require catheter replacement due to line failure. Other than line failure, which may be improved by 10\u2010 to 12\u2010hour infusion times, this product was found to be safe and practical for short\u2010term peripheral parenteral nutrition in dogs.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1748-5827.2006.00173.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T15:39:26Z","timestamp":1157038766000},"page":"518-523","source":"Crossref","is-referenced-by-count":26,"title":["Prospective evaluation of a peripherally administered three\u2010in\u2010one parenteral nutrition product in dogs"],"prefix":"10.1111","volume":"47","author":[{"given":"M. L.","family":"Chandler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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