{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T04:37:56Z","timestamp":1725597476224},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>The elevated urinary corticoid\/creatinine ratios of an 11\u2010year\u2010old Jack Russell terrier with polyuria were suppressible in a high\u2010dose dexamethasone suppression test, which was suggestive of pituitary\u2010dependent hyperadrenocorticism. The absence of physical and routine\u2010laboratory changes compatible with hyperadrenocorticism and the relatively high plasma thyroxine concentration were the impetus for additional studies of thyroid and adrenocortical functions. A high plasma thyroxine concentration (62 nmol\/l; 5\u00b70 \u03bcg\/100 ml) suggested the presence of hyperthyroidism. Radiography,<jats:sup>99m<\/jats:sup>TcO<jats:sub>4<\/jats:sub><jats:sup>\u2212<\/jats:sup>scintigraphy, ultrasonography, computed tomography and cytology revealed a hyperfunctioning intrathoracic thyroid tumour. In the low\u2010dose dexamethasone suppression test, the plasma cortisol concentration exceeded the reference value of 40 nmol\/l (1\u00b74 \u03bcg\/100 ml) at eight hours after dexamethasone administration (0\u00b701 mg\/kg intravenously), a test result compatible with hyperadrenocorticism. In conclusion, this report represents the first case of a dog with an autonomously hyperfunctioning thyroid tumour in the thorax. The elevated urinary corticoid excretion and the positive low\u2010dose dexamethasone suppression test may be explained by alterations in cortisol metabolism, the stress of the hyperthyroid state or both.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2006.00233.x","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T18:16:59Z","timestamp":1172859419000},"page":"283-287","source":"Crossref","is-referenced-by-count":8,"title":["Hyperthyroidism due to an intrathoracic tumour in a dog with test results suggesting hyperadrenocorticism"],"prefix":"10.1111","volume":"48","author":[{"given":"Q. E. 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