{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:14:01Z","timestamp":1697343241210},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p> <jats:bold>Carboplatin is usually a well\u2010tolerated drug and has many applications in veterinary oncology. The side effects of carboplatin described in the veterinary literature include myelotoxicity, nephrotoxicity, digestive and appetite disorders. In 114 dogs treated by single\u2010agent chemotherapy with carboplatin, we observed a rate of non\u2010haematological toxicities of 19\u00b73% (personal observation). This case report describes the first case of cutaneous delayed\u2010hypersensitivity to carboplatin in a dog, diagnosed according to the official ABON\u2010system, which determines a causal association between a suspected product and a reported reaction (A=probable, B=possible, O=unclassifiable and N=unlikely), and an experimental intradermal skin test. Antihistamines were used to treat the reaction, and future carboplatin treatments were adjusted by premedication with corticosteroids, prolonged infusion and a reduction of 20% of the first dose of carboplatin. No further reactions were noted during the following treatments.<\/jats:bold> <\/jats:p>","DOI":"10.1111\/j.1748-5827.2010.01002.x","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T14:05:19Z","timestamp":1291212319000},"page":"654-656","source":"Crossref","is-referenced-by-count":1,"title":["Probable cutaneous hypersensitivity to carboplatin single\u2010agent chemotherapy in a dog"],"prefix":"10.1111","volume":"51","author":[{"given":"D.","family":"Lanore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sayag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D32FW0G1XX","article-title":"Delayed type hypersensitivity: current theories with an historic perspective","volume":"5","author":"Black C.A.","year":"1999","journal-title":"Dermatology Online Journal"},{"key":"e_1_2_5_3_1","unstructured":"Committee forVeterinaryMedicinalProducts. 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