{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:49:45Z","timestamp":1790084985356,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T00:00:00Z","timestamp":1330905600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjective<\/jats:sc>:<\/jats:bold>To assess if there are any ultrasonographic features that may enable tentative diagnosis of hepatic parenchymal disease.<\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>:<\/jats:bold>Records of 371 dogs that had abdominal ultrasonography and abnormal liver on biopsy or necropsy were reviewed.<\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>:<\/jats:bold>Histological diagnoses were hepatitis (n=77), nodular hyperplasia (n=47), vacuolar change (n=45), fibrosis (n=32), primary hepatic carcinoma (n=30), lymphoma (n=28), metastatic neoplasia (n=27), necrosis (n=21), lipidosis (n=17), haemangiosarcoma (n=13), round cell tumour (n=9), hepatocellular adenoma (n=8), degenerative change (n=6), steroid hepatopathy (n=7) and extramedullary haematopoiesis (n=4). The most prevalent ultrasonographic features were multifocal lesions (63% livers with haemangiosarcoma and 43% livers with hepatocellular carcinoma), diffuse lesions (71% livers with steroid hepatopathy, 44% livers with fibrosis and 40% livers with vacuolar hepatopathy), hyperechoic lesions (71% livers with steroid hepatopathy, 41% livers with lipidosis and 38% livers with fibrosis), heterogeneous lesions (62% livers with haemangiosarcoma), hepatomegaly (43% livers with steroid hepatopathy) and peritoneal fluid (62% livers with haemangiosarcoma). Target lesions were associated with malignancy in 67% instances. Marked variability in ultrasonographic appearance of lesions was observed for all diagnoses, and no statistically significant associations between ultrasonographic appearance and diagnosis were found.<\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc>S<jats:sc>ignificance<\/jats:sc>:<\/jats:bold>Histological examination remains essential for diagnosis of canine hepatic disease.<\/jats:p>","DOI":"10.1111\/j.1748-5827.2011.01184.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T23:27:04Z","timestamp":1330990024000},"page":"168-173","source":"Crossref","is-referenced-by-count":53,"title":["Lack of associations between ultrasonographic appearance of parenchymal lesions of the canine liver and histological diagnosis"],"prefix":"10.1111","volume":"53","author":[{"given":"C. M. 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