{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:32:16Z","timestamp":1761708736678},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjectives<\/jats:sc>: To describe the echocardiographic findings and pedigree analysis of golden retrievers with subvalvular aortic stenosis.<\/jats:bold><\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>: Seventy\u2010three golden retrievers were evaluated by auscultation and echocardiography. A subcostal continuous\u2010wave Doppler aortic velocity \u00ea2\u00b75 m\/s and presence of a left basilar systolic ejection murmur were required for diagnosis of subvalvular aortic stenosis. Three echocardiographic characteristics were recorded: evidence of aortic insufficiency, subvalvular ridge or left ventricular hypertrophy. A disease status score was calculated by totalling the number of echocardiographic \u2010characteristics per subject.<\/jats:bold><\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>: Thirty\u2010two of 73 dogs were affected and their aortic velocities were as follows: range 2\u00b75 to 6\u00b78 m\/s, median 3\u00b74 m\/s and standard deviation 1\u00b72 m\/s. Echocardiographic characteristics of 32 affected dogs were distributed as follows: left ventricular hypertrophy 12 of 32, aortic insufficiency 20 of 32 and subvalvular ridge 20 of 32. Disease status score ranged from 0 to 3 with a median of 2. There was a statistically significant correlation between aortic velocity and disease status score (r=0\u00b7644, P&lt;0\u00b70001). Subvalvular aortic stenosis was observed in multiple generations of several families and appears familial.<\/jats:bold><\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc> S<jats:sc>ignificance<\/jats:sc>: Subvalvular aortic stenosis in the golden retriever is familial. Severity of stenosis correlates well with cumulative presence of echocardiographic characteristics (left ventricular hypertrophy, subvalvular ridge and aortic insufficiency).<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2011.01187.x","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T11:42:50Z","timestamp":1331725370000},"page":"213-216","source":"Crossref","is-referenced-by-count":20,"title":["Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings"],"prefix":"10.1111","volume":"53","author":[{"given":"J. A.","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Meurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. L.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Lahmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Lehmkuhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"457","volume-title":"Textbook of Canine and Feline Cardiology, Principles and Clinical Practice","author":"Buchanan J. 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