{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:49:49Z","timestamp":1791265789480,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjective<\/jats:sc>: To assess the value of thyroid scintigraphy to determine thyroid status in dogs with hypothyroidism and various non\u2010thyroidal illnesses.<\/jats:bold><\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>: Thyroid hormone concentrations were measured and quantitative thyroid scintigraphy performed in 21 dogs with clinical and\/or clinicopathological features consistent with hypothyroidism.<\/jats:bold><\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>: In 14 dogs with technetium thyroidal uptake values consistent with euthyroidism, further investigations supported non\u2010thyroidal illness.<\/jats:bold><\/jats:p><jats:p><jats:bold>In five dogs with technetium thyroidal uptake values within the hypothyroid range, primary hypothyroidism was confirmed as the only disease in four. The remaining dog had pituitary\u2010dependent hyperadrenocorticism.<\/jats:bold><\/jats:p><jats:p><jats:bold>Two dogs had technetium thyroidal uptake values in the non\u2010diagnostic range. One dog had iodothyronine concentrations indicative of euthyroidism. In the other, a dog receiving glucocorticoid therapy, all iodothyronine concentrations were decreased.<\/jats:bold><\/jats:p><jats:p><jats:bold>Markedly asymmetric technetium thyroidal uptake was present in two dogs. All iodothyronine concentrations were within reference interval but canine thyroid stimulating hormone concentration was elevated in one. Non\u2010thyroidal illness was identified in both cases.<\/jats:bold><\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc>S<jats:sc>ignificance<\/jats:sc>: In dogs, technetium thyroidal uptake is a useful test to determine thyroid function. However, values may be non\u2010diagnostic, asymmetric uptake can occur and excess glucocorticoids may variably suppress technetium thyroidal uptake and\/or thyroid hormone concentrations. Further studies are necessary to evaluate quantitative thyroid scintigraphy as a gold standard method for determining canine thyroid function.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2011.01205.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T08:37:34Z","timestamp":1335429454000},"page":"278-285","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of the value of quantitative thyroid scintigraphy for determination of thyroid function in dogs"],"prefix":"10.1111","volume":"53","author":[{"given":"R. E.","family":"Shiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. T.","family":"Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1997.tb00862.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","unstructured":"Atkins H. L. Klopper J. F. Lambrecht R. M.&Wolf A. P.(1973)A comparison of technetium 99M and iodine 123 for thyroid imaging.American Journal of Roentgenology Radium Therapy and Nuclear Medicine117 195\u2013201","DOI":"10.2214\/ajr.117.1.195"},{"key":"e_1_2_5_4_1","first-page":"145","article-title":"Thyroid volumetric measurement and quantitative thyroid scintigraphy in dogs","volume":"46","author":"Balogh L.","year":"1998","journal-title":"Acta Veterinaria Hungarica"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","unstructured":"Berson S. A.&Yalow R. S.(1952)The effect of cortisone on the iodine accumulating function of the thyroid gland in euthyroid subjects.Journal of Clinical Endocrinology and Metabolism12 407\u2013422","DOI":"10.1210\/jcem-12-4-407"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02467.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01021.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(2007)21[25:AOTFID]2.0.CO;2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00253469"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-88-2-504"},{"key":"e_1_2_5_11_1","volume-title":"Canine thyroid function: a clinical and clinicopathological investigation. PhD thesis. Department of Veterinary Clinical Studies","author":"Dixon R. M.","year":"1999"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1999.tb03040.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.17.481"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","unstructured":"Ferguson D. C.(2007)Testing for hypothyroidism in dogs.Veterinary Clinics of North America: Small Animal Practice37 647\u2013669","DOI":"10.1016\/j.cvsm.2007.05.015"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","unstructured":"Fisher D. A. Oddie T. H. Johnson D. E.&Nelson J. C.(1975)The diagnosis of Hashimoto\u2019s thyroiditis.Journal of Clinical Endocrinology qnd Metabolism40 795\u2013801","DOI":"10.1210\/jcem-40-5-795"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-89-21830"},{"key":"e_1_2_5_17_1","first-page":"516","article-title":"Clinical applications of the thyroidal I131 uptake test in the dog","volume":"135","author":"Kaneko J. J.","year":"1959","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.765"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.3.1669"},{"key":"e_1_2_5_20_1","unstructured":"Kyzar J. R. Chester D. K.&Hightower D.(1972)Comparison of T\u20103 T\u20104 tests and radioactive iodine uptake determinations in the dog.Veterinary Medicine Small Animal Clinician67 321\u2013322"},{"key":"e_1_2_5_21_1","first-page":"412","article-title":"Diagnosis of thyroid gland function in the dog","volume":"23","author":"Lombardi M. H.","year":"1962","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00418.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2460\/ajvr.1993.54.01.130","article-title":"Effects of oral administration of anti\u2010inflammatory doses of prednisone on thyroid hormone response to thyrotropin releasing hormone and thyrotropin in clinically normal dogs","volume":"54","author":"Moore G. E.","year":"1993","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03238.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2460\/javma.1994.204.05.761","article-title":"Hypothyroidism in dogs: 66 cases (1987\u20101992)","volume":"204","author":"Panciera D. L.","year":"1994","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-070202858-8.50008-7"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01521.x"},{"key":"e_1_2_5_28_1","unstructured":"Rijnberk A.(1971)Iodine metabolism and thyroid disease in the dog. PhD thesis.Faculty of Veterinary Medicine Utrecht University Utrecht"},{"key":"e_1_2_5_29_1","volume-title":"Endocrine Imaging","author":"Sandler M. P.","year":"1992"},{"key":"e_1_2_5_30_1","first-page":"215","article-title":"Use of recombinant human thyroid\u2010stimulating hormone for thyrotropin stimulation test in euthyroid dogs","volume":"41","author":"Sauve F.","year":"2000","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03230320036026"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","unstructured":"Sherer M. G.&Siefring B. N.(1956)Effect of prednisone and prednisolone on thyroid function with special reference to thyroxine\u2010binding protein in nephrosis.Journal of Clinical Endocrinology and Metabolism16 643\u2013652","DOI":"10.1210\/jcem-16-5-643"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0412"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02386810"},{"key":"e_1_2_5_35_1","first-page":"2000","article-title":"Effect of prednisone on thyroid gland morphology and plasma thyroxine and triiodothyronine concentrations in the dog","volume":"44","author":"Woltz H. H.","year":"1983","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450500513997"}],"container-title":["Journal of Small Animal Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1748-5827.2011.01205.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1748-5827.2011.01205.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:00:27Z","timestamp":1713913227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1748-5827.2011.01205.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1748-5827.2011.01205.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1748-5827.2011.01205.x","archive":["Portico"],"relation":{},"ISSN":["0022-4510","1748-5827"],"issn-type":[{"value":"0022-4510","type":"print"},{"value":"1748-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}