{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:18Z","timestamp":1791639138335,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>O<jats:sc>bjectives<\/jats:sc>: To evaluate accuracy and precision of a hand\u2010held ketone meter measuring \u03b2\u2010hydroxybutyrate and to determine its diagnostic performance to rule out ketoacidaemia in diabetic cats.<\/jats:bold><\/jats:p><jats:p><jats:bold>M<jats:sc>ethods<\/jats:sc>: The ketone meter was validated by calculating within\u2010day precision at different \u03b2\u2010hydroxybutyrate concentrations and by comparison with a laboratory method.<\/jats:bold><\/jats:p><jats:p><jats:bold>To determine its diagnostic performance to diagnose ketoacidaemia, 217 sets of data (venous blood gas analysis and \u03b2\u2010hydroxybutyrate measurements) were retrospectively analysed. Sensitivities and specificities were calculated with the help of receiver\u2010operating characteristic curves.<\/jats:bold><\/jats:p><jats:p><jats:bold>R<jats:sc>esults<\/jats:sc>: The ketone meter reliably detected \u03b2\u2010hydroxybutyrate at concentrations &gt;0\u00b71 mmol\/L and reproducibility was acceptable. Measurements highly correlated with laboratory results (r=0\u00b797; P&lt;0\u00b7001), but a significant negative bias was found at high concentrations. A \u03b2\u2010hydroxybutyrate concentration of &gt;2\u00b755 mmol\/L had a sensitivity of 94% and a specificity of 68% for diagnosing ketoacidaemia. Many cats with high \u03b2\u2010hydroxybutyrate concentrations and normal blood pH had an elevated chloride gap suggestive of superimposed hypochloraemic metabolic alkalosis.<\/jats:bold><\/jats:p><jats:p><jats:bold>C<jats:sc>linical<\/jats:sc>S<jats:sc>ignificance<\/jats:sc>: The commercially available point\u2010of\u2010care ketone meter Precision Xtra is a valid tool to measure \u03b2\u2010hydroxybutyrate in diabetic cats. Concentration &lt;2\u00b755 mmol\/L enable ketoacidaemia to be excluded and should lead to redirection of differential diagnoses.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2012.01204.x","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T10:06:46Z","timestamp":1335434806000},"page":"328-331","source":"Crossref","is-referenced-by-count":21,"title":["Point\u2010of\u2010care \u03b2\u2010hydroxybutyrate measurement for the diagnosis of feline diabetic ketoacidaemia"],"prefix":"10.1111","volume":"53","author":[{"given":"F. 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