{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:47:18Z","timestamp":1771490838854,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:bold>To investigate the in vitro efficacy of commercially available topical otic preparations (\u201cear cleaners\u201d) against<jats:italic>Pseudomonas spp<\/jats:italic>. isolated from canine ear infections.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>Between January and May 2011, 50 isolates that were morphologically and phenotypically confirmed as<jats:italic>Pseudomonas spp<\/jats:italic>. were isolated from 48 dogs that had been identified with clinical signs of otitis externa and media at a referral dermatology clinic in the north west of the UK. The in vitro efficacy of eight different topical preparations against these isolates was investigated using an in\u2010agar inhibition test.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Of the eight preparations tested, three showed consistently good in vitro activity against<jats:italic>Pseudomonas spp<\/jats:italic>., while a further three were consistently ineffective. For the remaining two \u2010preparations, in vitro efficacy was variable and inconsistent.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>Topical treatment with ear cleaners is considered to be a valuable adjunct in the treatment of canine otitis that involves multi\u2010antimicrobial\u2010resistant organisms such as<jats:italic>Pseudomonas spp<\/jats:italic>. Where treatment with antimicrobials is not an option, the use of these preparations, as a sole form of therapy, may be effective in some cases. As a comparison with other similar studies looking at the activity of ear cleaners against bacterial isolates from otitis, this study uses isolates from 50 ears from 48 dogs providing a significant number of isolates for analysis.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-5827.2012.01262.x","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T05:38:10Z","timestamp":1344922690000},"page":"599-603","source":"Crossref","is-referenced-by-count":16,"title":["The susceptibility of<i>Pseudomonas spp<\/i>. isolated from dogs with otitis to topical ear cleaners"],"prefix":"10.1111","volume":"53","author":[{"given":"S. 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