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An acetylcholine receptor antibody titre was consistent with acquired myasthenia gravis. Withdrawal of methimazole and treatment with pyridostigmine was followed by resolution of clinical signs and reduction of the acetylcholine \u2010receptor antibody titre. Medical control of hyperthyroidism was subsequently achieved with carbimazole, administered in conjunction with pyridostigmine, and no recurrence of clinical signs was observed. Myasthenia gravis is an uncommon but clinically significant adverse effect of methimazole therapy in cats, and may be caused by immunomodulatory properties of this drug. An adverse drug reaction should be considered in cats receiving methimazole that develop myasthenia gravis, and potentially also other immune\u2010mediated disorders.<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.1748-5827.2012.01273.x","type":"journal-article","created":{"date-parts":[[2012,9,8]],"date-time":"2012-09-08T07:01:42Z","timestamp":1347087702000},"page":"661-663","source":"Crossref","is-referenced-by-count":16,"title":["Immune\u2010mediated myasthenia gravis in a methimazole\u2010treated cat"],"prefix":"10.1111","volume":"53","author":[{"given":"E. T.","family":"Bell","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science, Veterinary Hospital The University of Melbourne 250 Princes Highway Werribee VIC 3030 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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