{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:25:48Z","timestamp":1761863148708},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:bold>To determine whether or not dogs develop a deficiency of ascorbic acid during hospitalisation in an intensive care unit.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:bold>Blood samples were collected daily for up to three days from dogs hospitalised in an intensive care unit for 36 to 72\u2009hours (n\u2009=\u200916) or \u00ea72 hours (n\u2009=\u200920) and from healthy dogs (n\u2009=\u200913). Plasma total ascorbic acid concentrations were measured using a colorimetric method involving a reaction between ascorbic acid, 2,6 dichlorophenol\u2010indophenol, thiourea and dinitrophenyl hydrazine. Additionally, clinical data were recorded for each patient.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Dogs hospitalised for \u00ea72 hours had significantly greater plasma ascorbic acid concentrations on day 3 compared to days 1 and 2. There was no difference in plasma ascorbic acid concentrations between days 1 and 2 for dogs hospitalised for 36 to 72\u2009hours. Plasma ascorbic acid concentrations were significantly greater for each day of sampling for the hospitalised dogs compared to the control dogs.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p><jats:bold>Plasma ascorbic acid concentrations appear to increase during hospitalisation, and supplementation may not be indicated in dogs hospitalised in an intensive care unit.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-5827.2012.01290.x","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T07:02:23Z","timestamp":1349074943000},"page":"652-656","source":"Crossref","is-referenced-by-count":3,"title":["Hyperascorbaemia in dogs admitted to a teaching hospital intensive care unit"],"prefix":"10.1111","volume":"53","author":[{"given":"E.","family":"Groth","sequence":"first","affiliation":[{"name":"Comparative Internal Medicine Laboratory, College of Veterinary Medicine University of Missouri  Columbia MO 65211 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Honaker","sequence":"additional","affiliation":[{"name":"Comparative Internal Medicine Laboratory, College of Veterinary Medicine University of Missouri  Columbia MO 65211 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Osterbur","sequence":"additional","affiliation":[{"name":"Comparative Internal Medicine Laboratory, College of Veterinary Medicine University of Missouri  Columbia MO 65211 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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