{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:20:06Z","timestamp":1697433606468},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Keypoints<\/jats:title><jats:p>\u2022\u2002Radioiodine and thionamide treatment are the most frequently used treatment modalities for thyrotoxicosis in Europe and North America with surgery being reserved for selected cases.<\/jats:p><jats:p>\u2022\u2002In our clinic patients were offered all three modalities via simultaneous interview with an endocrinologist and a surgeon, with international risk benefit data for radioiodine and thionamide therapy, and local risk benefit data for total thyroidectomy provided.<\/jats:p><jats:p>\u2022\u2002When given the choice, at least 15% of patients opted for total thyroidectomy over the other modalities.<\/jats:p><jats:p>\u2022\u2002In our series of 100 consecutive surgical patients there was a 4% malignancy rate.<\/jats:p><jats:p>\u2022\u2002Total thyroidectomy should be offered equally, with radioiodine and thionamide treatment, as a first line treatment modality in the management of thyrotoxicosis.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2006.01150.x","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T13:27:56Z","timestamp":1142861276000},"page":"160-162","source":"Crossref","is-referenced-by-count":2,"title":["How we do it: Surgery should be considered equally with I<sup>131<\/sup> and thionamide treatment as first\u2010line therapy for thyrotoxicosis"],"prefix":"10.1111","volume":"31","author":[{"given":"R.J.A.","family":"England","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jabreel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.3-1-11"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00629.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406163302407"},{"key":"e_1_2_6_5_2","first-page":"103","article-title":"Incidence of hypothyroidism occurring long after iodine\u2010131 therapy for hyperthyroidism","volume":"23","author":"Holm L.E.","year":"1982","journal-title":"J. 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