{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:31:42Z","timestamp":1769747502824,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To assess the use of intra\u2010operative parathyroid hormone (PTH) level monitoring as a predictor of persistent hypoparathyroidism after total parathyroidectomy in renal hyperparathyroidism.<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> University Teaching Hospital Otorhinolaryngology and Head and Neck Surgery Unit.<\/jats:p><jats:p><jats:bold>Participants:\u2002<\/jats:bold> All patients with renal hyperparathyroidism undergoing parathyroidectomy between January 2004 and July 2005. Twenty\u2010nine patients were identified.<\/jats:p><jats:p><jats:bold>Main outcome measures:\u2002<\/jats:bold> Comparison is made between pre\u2010 and intra\u2010operative PTH levels (ioPTH) in patients who at 3\u2003months postoperatively maintained hypoparathyroidism and patients who did not. Results were analysed to see whether ioPTH predicts maintenance of the hypoparathyroid state.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean preoperative PTH level was 932\u2003pg\/L (range: 58\u20131808). The mean postoperative PTH level was 147\u2003pg\/L (range: 16\u2013498). The mean 3\u2010month PTH level was 47\u2003pg\/L (range: &lt;1\u2013515). The mean postoperative PTH level for patients with a persistently high PTH level at 3\u2003months was 286\u2003pg\/L (range: 272\u2013299), compared with 63\u2003pg\/mL (16\u2013160) in patients remaining normparathyroid, and 159\u2003pg\/L (range: 39\u2013498) for patients with persistent hypoparathyroidism. If the normoparathyroid state is strictly considered to be failure following total parathyroidectomy, ioPTH is not predictive of hypoparathyroidism. However, ioPTH is indicative of biochemical resolution of the hyperparathyroid state (normo\u2010 or hypoparathyroidism).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We conclude that the use of ioPTH monitoring in the surgical management of secondary hyperparathyroidism fails to predict persistent hypoparathyroidism following total parathyroidectomy, but does predict biochemical resolution of hyperparathyroidism.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2006.01200.x","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T10:25:35Z","timestamp":1148379935000},"page":"198-203","source":"Crossref","is-referenced-by-count":21,"title":["Intra\u2010operative parathyroid hormone monitoring in secondary hyperparathyroidism: is it useful?"],"prefix":"10.1111","volume":"31","author":[{"given":"A.","family":"Roshan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.A.","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7641-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7708-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6619-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.06.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.05.060"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.2.164"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046084"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.026450"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.110431"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.3.341"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-001-0387-z"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010220"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329202900106"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.6.632"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.389"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050596"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6574.743"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.138"},{"key":"e_1_2_6_20_2","first-page":"685","article-title":"Long\u2010term follow\u2010up after total parathyroidectomy without parathyroid reimplantation in chronic renal failure","volume":"87","author":"Ljutic D.","year":"1994","journal-title":"Q. 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