{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:29:31Z","timestamp":1772814571278,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Keypoints<\/jats:title><jats:p>\u2022\u2002Sialorrhoea can be a significant problem in both adults and children and can cause both physical and psychosocial problems.<\/jats:p><jats:p>\u2022\u2002Botulinum toxin has enjoyed an emergence in the treatment of sialorrhoea, a systematic review of the evidence for botulinum toxin reveals two randomised controlled trials (RCTs) and four other trials that fulfilled our inclusion criteria.<\/jats:p><jats:p>\u2022\u2002Both RCTs demonstrate the effectiveness of botulinum toxin in the management of sialorrhoea.<\/jats:p><jats:p>\u2022\u2002There was no clear evidence for one antigenic type of botulinum toxin over another and minimal evidence for the optimal dose of botulinum toxin for each antigenic type. No advantage is conferred in using ultrasound guidance in injecting the glands.<\/jats:p><jats:p>\u2022\u2002None of the RCTs or other studies directly compared submandibular <jats:italic>versus<\/jats:italic> parotid injection or directly compared botulinum toxin against surgery. Minor side effects were reported in one of the RCTs but overall botulinum toxin is a safe, minimally invasive and effective means in the treatment of sialorrhoea with the potential to become the treatment of choice.<\/jats:p><jats:p>\u2022\u2002Our review demonstrates that further randomised controlled trials are required to more fully evaluate this new modality of treatment.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2006.01263.x","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T13:34:12Z","timestamp":1153920852000},"page":"267-272","source":"Crossref","is-referenced-by-count":47,"title":["Botulinum toxin in the management of sialorrhoea: a systematic review"],"prefix":"10.1111","volume":"31","author":[{"given":"M.","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Reza Nouraei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"2629","article-title":"Sialorrhoea: a management challenge","volume":"69","author":"Hockstein N.G.","year":"2004","journal-title":"Am. 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