{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:20:47Z","timestamp":1772526047408,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>Clin. Otolaryngol.<\/jats:italic> 2012, <jats:bold>37<\/jats:bold>, 291\u2013296<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Down\u2019s syndrome is the commonest genetic condition. ENT problems are common in these children and can affect their development and quality of life.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> English literature review and experience of the senior author in managing ENT problems in children and adults with Down\u2019s syndrome.<\/jats:p><jats:p><jats:bold>Search strategy:\u2002<\/jats:bold> We carried out a Medline search on 31\/03\/2012 of English language publications using the following keywords: Down\/Down\u2019s syndrome, hearing loss, ear infections, sleep apnoea, thyroid.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The prevalence, presenting features and management of many common ENT conditions are significantly different in children who have Down\u2019s syndrome. This is particularly true of otitis media with effusion and sleep\u2010disordered breathing.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The outpatient consultation for a child with Down\u2019s syndrome should assess a range of specific ENT problems affecting this patient group including hearing issues, sleep\u2010disordered breathing, recurrent upper respiratory tract infections, as well as other health conditions like hypothyroidism, atlantoaxial instability and cardiac issues, which can potentially affect the management of the patient.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2012.02482.x","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T06:16:48Z","timestamp":1346134608000},"page":"291-296","source":"Crossref","is-referenced-by-count":10,"title":["An evidence\u2010based approach to the 12\u2010min consultation for a child with Down\u2019s syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"V.","family":"Malik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.U.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.Z.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1471-0528.1987.tb03115.x","article-title":"Estimating a woman\u2019s risk of having a pregnancy associated with Down syndrome using her age and serum alphafetoprotein level","volume":"94","author":"Cuckle H.S.","year":"1984","journal-title":"Br. 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