{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:32:26Z","timestamp":1792409546237,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>Clin. Otolaryngol.<\/jats:italic> 2012, <jats:bold>37<\/jats:bold>, 271\u2013275<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To evaluate the efficacy of Nd:YAG laser photocoagulation with that of liquid paraffin plus antiseptic cream in the management of recurrent epistaxis.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> Prospective clinical study. Eighty consecutive patients with histories of recurrent epistaxis were randomly assigned to receive treatment in an outpatient setting consisting of either a combination of liquid paraffin plus antiseptic cream (group 1) or Nd:YAG laser photocoagulation (group 2).<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> University\u2010affiliated teaching hospital.<\/jats:p><jats:p><jats:bold>Participants:\u2002<\/jats:bold> Eighty consecutive patients who suffered from recurrent anterior epistaxis presented to the Otolaryngology Department at the Eye and ENT Hospital, Fudan University between February 2011 and June 2011.<\/jats:p><jats:p><jats:bold>Main outcome measures:\u2002<\/jats:bold> The following outcome measures were assessed: bleeding intensity, bleeding frequency 4 and 12\u2003weeks after treatment (0\u2003=\u2003no bleeding, 1\u2003=\u2003reduced bleeding, 2\u2003=\u2003the same, 3\u2003=\u2003worse), participant\u2019s perception of discomfort during the management (grade 0\u201310, where 10 is the worst pain) and complications.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> At 12\u2003weeks, 85% of laser patients <jats:italic>versus<\/jats:italic> 40% of control patients had no reported bleeding. The outcome score at 4\u2003weeks after treatment showed no significant difference between the two groups (<jats:italic>P<\/jats:italic>\u2003=\u20030.130, <jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05); however, the outcome score at 12\u2003weeks after treatment showed a significant difference between the two groups (<jats:italic>P<\/jats:italic>\u2003=\u20030.000, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). The median and mean\u2003\u00b1\u2003<jats:sc>sd<\/jats:sc> pain levels experienced were 5.0 and 5.2\u2003\u00b1\u20032.2. Both groups had no complications.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> It can be concluded that Nd:YAG laser photocoagulation is a preferable therapy in the treatment of recurrent epistaxis, especially in terms of long\u2010lasting efficacy. The level of pain associated with the procedure was tolerated. It is a simple, easy, safe and rapid therapy, which can be performed in an office setting.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2012.02509.x","type":"journal-article","created":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T12:01:47Z","timestamp":1338724907000},"page":"271-275","source":"Crossref","is-referenced-by-count":7,"title":["A prospective randomised controlled trial of Nd:YAG laser photocoagulation versus liquid paraffin plus antiseptic cream in the treatment of recurrent epistaxis"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"272","volume-title":"Scott Brown\u2019s Otolaryngology","author":"Shaheen O.H.","year":"1987"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2008.01.003"},{"key":"e_1_2_7_4_2","first-page":"123","article-title":"Epidemiological notes on nasal bleeding","volume":"31","author":"Vaamonde Lago P.","year":"2004","journal-title":"An. Otorrinolaringol. Ibero Am."},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30390-X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00405-010-1208-0","article-title":"Prospective, randomized, controlled clinical trial of Ankaferd Blood Stopper in patients with acute anterior epistaxis","volume":"267","author":"Aysenur M.T.","year":"2010","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"e_1_2_7_7_2","first-page":"373","article-title":"Endovascular treatment of intractable epistaxis\u2014results of a 4\u2010year local audit","volume":"94","author":"Duncan I.C.","year":"2004","journal-title":"S. Afr. Med. J."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.025007"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.11.031"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00236.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100306"},{"key":"e_1_2_7_12_2","first-page":"156","article-title":"Characterization of nasal paraffinoma following septorhinoplasty by attenuated total reflection \u2013 fourier transform infrared spectroscopy (ATR\u2010FTIR)","volume":"44","author":"Gil\u2010Carcedo L.M.","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(95)00106-9"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-4486.2012.02509.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-4486.2012.02509.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:09:42Z","timestamp":1698718182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-4486.2012.02509.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1749-4486.2012.02509.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-4486.2012.02509.x","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}