{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:39:54Z","timestamp":1782254394494,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>Clin. Otolaryngol.<\/jats:italic> 2012, <jats:bold>37<\/jats:bold>, 283\u2013290<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To evaluate the treatment effect of prednisolone and\/or valaciclovir in Bell\u2019s palsy patients with different baseline severity of palsy.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> Patient data were collected from the Scandinavian Bell\u2019s Palsy Study, a prospective, randomised, double\u2010blind, placebo\u2010controlled, multi\u2010centre trial.<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> Sixteen otorhinolaryngological centres in Sweden and one in Finland.<\/jats:p><jats:p><jats:bold>Participants:\u2002<\/jats:bold> Altogether, 829 patients aged 18\u201375\u2003years were treated within 72\u2003h of palsy onset. Patients were randomly assigned to treatment with prednisolone plus placebo (<jats:italic>n\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>210), valaciclovir plus placebo (<jats:italic>n\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>207), prednisolone plus valaciclovir (<jats:italic>n<\/jats:italic>\u2003=\u2003206), placebo plus placebo (<jats:italic>n<\/jats:italic>\u2003=\u2003206). Follow\u2010up was 12\u2003months.<\/jats:p><jats:p><jats:bold>Main outcome measures:\u2002<\/jats:bold> Facial function was assessed using the Sunnybrook grading scale at baseline and at 12\u2003months. Complete recovery was defined as Sunnybrook score\u2003=\u2003100.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All patients, regardless of baseline severity, showed significantly higher complete recovery rates if treated with prednisolone compared with no prednisolone. In patients with severe palsy, recovery at 12\u2003months was 51% with prednisolone treatment <jats:italic>versus<\/jats:italic> 31% without prednisolone (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). Corresponding results were 68%<jats:italic>versus<\/jats:italic> 51% (<jats:italic>P<\/jats:italic>\u2003=\u20030.004) for moderate, and 83%<jats:italic>versus<\/jats:italic> 73% (<jats:italic>P<\/jats:italic>\u2003=\u20030.02) for mild palsy. In patient groups with moderate and mild palsy at baseline, significantly fewer prednisolone\u2010treated patients had synkinesis at 12\u2003months (<jats:italic>P<\/jats:italic>\u2003=\u20030.04 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001, respectively). For patients with severe palsy at baseline, prednisolone <jats:italic>versus<\/jats:italic> no prednisolone made no significant difference regarding synkinesis at 12\u2003months. Valaciclovir did not add any significant effect to prednisolone regarding recovery rate or synkinesis at 12\u2003months.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Prednisolone treatment resulted in higher complete recovery rates, regardless of severity at baseline. Prednisolone treatment should be considered in all patients irrespective of degree of palsy.<\/jats:p>","DOI":"10.1111\/j.1749-4486.2012.02526.x","type":"journal-article","created":{"date-parts":[[2012,7,8]],"date-time":"2012-07-08T01:07:27Z","timestamp":1341709647000},"page":"283-290","source":"Crossref","is-referenced-by-count":37,"title":["Bell\u2019s palsy \u2013 the effect of prednisolone and\/or valaciclovir <i>versus<\/i> placebo in relation to baseline severity in a randomised controlled trial"],"prefix":"10.1111","volume":"37","author":[{"given":"S.","family":"Axelsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kanerva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stjernquist\u2010Desatnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"167","article-title":"Facial nerve disorders: update 1987","volume":"8","author":"May M.","year":"1987","journal-title":"Am. 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