{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:42:21Z","timestamp":1770694941620,"version":"3.49.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,17]],"date-time":"2006-12-17T00:00:00Z","timestamp":1166313600000},"content-version":"vor","delay-in-days":3547,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1111\/j.1749-6632.1997.tb52071.x","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T06:04:07Z","timestamp":1166421847000},"page":"296-311","source":"Crossref","is-referenced-by-count":32,"title":["Rheumatoid Factor Autoantibodies in Health and Disease<sup>a<\/sup>"],"prefix":"10.1111","volume":"815","author":[{"given":"RIZGAR A.","family":"MAGEED","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIE","family":"B\u00d8RRETZEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SASHA P.","family":"MOYES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEITH M.","family":"THOMPSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JACOB B.","family":"NATVIG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,17]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.137.2.331"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.139.1.128"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb00832.x"},{"key":"e_1_2_11_5_2","first-page":"367","article-title":"Sequence analysis of immunoglobulin heavy\u2010chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation, but diverse CDR3","volume":"84","author":"Brown C. M.","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb55861.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60878-0"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/353765a0"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115007"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1868"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.2.487"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.1.109"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240808"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03596.x"},{"key":"e_1_2_11_15_2","first-page":"55","article-title":"Immunoglobulin classes, subclasses, and complexes of IgG rheumatoid factor in rheumatoid plasma cells","volume":"12","author":"Munthe E.","year":"1972","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350108"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36037.x"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350702"},{"key":"e_1_2_11_19_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0889-857X(21)00458-0","article-title":"Epidemiology of rheumatoid arthritis","volume":"21","author":"Alarcon G. S","year":"1995","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"e_1_2_11_20_2","first-page":"135","article-title":"Role of endothelium in the pathogenesis of rheumatoid synovitis","volume":"15","author":"Ziff M","year":"1993","journal-title":"Int. J. Tissue React."},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44499.x"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009749509100920"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90190-9"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809098793"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748909095400"},{"key":"e_1_2_11_26_2","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.4049\/jimmunol.140.9.3098","article-title":"Antigen specificities of human monoclonal and polyclonal IgM rheumatoid factors","volume":"140","author":"Sasso E. H.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_11_27_2","first-page":"13","article-title":"Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization","volume":"78","author":"Randen I.","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1988.tb02436.x"},{"key":"e_1_2_11_29_2","first-page":"190","article-title":"Fc epitopes for human rheumatoid factors and the relationships of rheumatoid factors to the Fc binding proteins of microorganisms. Scand","volume":"75","author":"Nardella F. A.","year":"1988","journal-title":"J. Rheumatol."},{"key":"e_1_2_11_30_2","first-page":"S166","article-title":"Healthy immunized donors (HIDs) and rheumatoid arthritis patients produce IgM rheumatoid factors (RF) that react differently with genetically engineered chimeric IgG antibodies (clgG)","volume":"38","author":"Bonagura V. R.","year":"1995","journal-title":"Arthritis Rheum."},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(84)90042-7"},{"key":"e_1_2_11_32_2","first-page":"881","article-title":"The effect of chemical modification on the antigenicity of human and rabbit immunoglobulin","volume":"30","author":"Hunneyball I. M.","year":"1976","journal-title":"G. Immunology"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.6.1514"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541285"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1994.tb03524.x"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274784"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(90)90063-6"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1993.tb01737.x"},{"key":"e_1_2_11_39_2","first-page":"473","article-title":"Restricted light chain subgroup expression in human rheumatoid factor paraproteins determined by monoclonal antibodies","volume":"59","author":"Mageed R. A.","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.6.2119"},{"key":"e_1_2_11_41_2","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.4049\/jimmunol.140.10.3411","article-title":"Incidence of two cross\u2010reactive idiotypes defines two mutually exclusive kappa light chain variable region subgroups for human rheumatoid factor paraproteins","volume":"140","author":"Crowley J. J.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330907"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03638.x"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90143-9"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/316412a0"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12917"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/328805a0"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.265"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.4.231"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230604"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211209"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.3.679"},{"key":"e_1_2_11_53_2","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.4049\/jimmunol.148.10.3296","article-title":"Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue","volume":"148","author":"Randen I.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90289-B"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.19"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1996.0021"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2639"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114841"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117040"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340312"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.2.550"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370614"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350316"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360314"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-6632.1997.tb52071.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-6632.1997.tb52071.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:23:43Z","timestamp":1695612223000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-6632.1997.tb52071.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1111\/j.1749-6632.1997.tb52071.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-6632.1997.tb52071.x","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}