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The \u03b2\u2010amyloid (A\u03b2) peptide is believed to play a central role in the pathogenesis of AD. <jats:italic>In vitro<\/jats:italic> experiments have shown that freshly solubilized A\u03b2 enhances constriction of cerebral and peripheral vessels. We proposed that <jats:italic>in vivo<\/jats:italic>, A\u03b2 would also have vasoactive properties. To test this hypothesis, we intraarterially infused freshly solubilized A\u03b2<jats:sub>1\u201340<\/jats:sub> in rats and observed changes in peripheral blood pressure, cerebral blood flow, and cerebrovascular resistance. We found that infusion of A\u03b2<jats:italic>in vivo<\/jats:italic> significantly increased the blood pressure in hypotensive rats but not in normotensive and hypertensive rats. Moreover, A\u03b2 infusion also resulted in a decreased blood flow and increased vascular resistance specifically in cerebral cortex but not in heart or kidneys. These data suggest that A\u03b2 has a direct and specific constrictive effect on cerebral vessels <jats:italic>in vivo<\/jats:italic>, which may contribute to the cerebral hypoperfusion observed early in the AD process.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2000.tb06363.x","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T14:39:26Z","timestamp":1138631966000},"page":"156-163","source":"Crossref","is-referenced-by-count":19,"title":["A\u03b2 Vasoactivity <i>in Vivo<\/i>"],"prefix":"10.1111","volume":"903","author":[{"given":"ZHIMING","family":"SUO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEORGE","family":"SU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDON","family":"PLACZEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMY","family":"KUNDTZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAMES","family":"HUMPHREY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FIONA","family":"CRAWFORD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIKE","family":"MULLAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004924"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000106613"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(95)00032-1"},{"key":"e_1_2_6_5_2","first-page":"741","article-title":"Neuroepidemiology of vascular and Alzheimer's dementia among African\u2010American women","volume":"87","author":"Harris Y.","year":"1995","journal-title":"J. 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