{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:06:24Z","timestamp":1778720784129,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T00:00:00Z","timestamp":1138579200000},"content-version":"vor","delay-in-days":2130,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> A number of studies have suggested that cerebral changes, particularly deep white matter lesions (WML) visualized on magnetic resonance imaging(MRI), may be involved in the genesis of late life depression. This has been confirmed in a prospective study which also found a relationship between the presence of WML and poor 3\u2010year outcome in elderly depressed subjects. Most studies find these lesions to predominate in frontal lobe and basal ganglia, supporting the hypothesis of \u201cfronto\u2010striatal\u201d dysfunction in depression. To investigate whether WML are associated with mood disturbance in dementia, proton density and T<jats:sub>2<\/jats:sub>\u2010weighted images were obtained in 80 subjects with dementia (dementia with Lewy bodies, <jats:styled-content><jats:italic>n<\/jats:italic>= 27<\/jats:styled-content>; Alzheimer's disease, <jats:styled-content><jats:italic>n<\/jats:italic>= 28<\/jats:styled-content>; vascular dementia, <jats:styled-content><jats:italic>n<\/jats:italic>= 25<\/jats:styled-content>) and 26 age\u2010matched normal controls. Periventricular lesions (PVL), white matter lesions (WML), and basal ganglia hyperintensities (BG) were visually rated blind to diagnosis using a semiquantitative scale. Frontal WML were associated with higher depression scores in patients with dementia, implying a common pathophysiology of depression irrespective of diagnosis. Further study of the neurobiological basis of WML is needed. This can best be achieved by serial clinical assessment combined with <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> MRI and neuropathological examination.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2000.tb06403.x","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T14:39:26Z","timestamp":1138631966000},"page":"482-489","source":"Crossref","is-referenced-by-count":59,"title":["The Association between White Matter Lesions on Magnetic Resonance Imaging and Noncognitive Symptoms"],"prefix":"10.1111","volume":"903","author":[{"given":"JOHN","family":"O'BRIEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT","family":"PERRY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT","family":"BARBER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANIL","family":"GHOLKAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALAN","family":"THOMAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,30]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb10146.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.5.617"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/386824a0"},{"key":"e_1_2_4_5_2","first-page":"7","article-title":"Quantitative cerebral anatomy in depression","volume":"50","author":"Coffey C.E.","year":"1993","journal-title":"Cereb. Anat."},{"key":"e_1_2_4_6_2","first-page":"604","article-title":"The anatomy of melancholia\u2010focal abnormalities of cerebral blood flow in major depression","volume":"22","author":"Beach C.J.","year":"1992","journal-title":"Psychol. Med."},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90014-B"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199608)11:8<681::AID-GPS426>3.0.CO;2-U"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.4.477"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90041-V"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004432"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7164.982"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930060702"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90107-L"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.1.66"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_4_17_2","first-page":"250","article-title":"Vascular dementia: diagnostic criteria for research studies","volume":"43","author":"Roman G.C.","year":"1993","journal-title":"Report of the NINDS-AIRENS international workshop. Neurology"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_4_19_2","first-page":"698","article-title":"CAMDEX","volume":"149","author":"Roth M.","year":"1986","journal-title":"A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.6.911"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.761"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.12.1458"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530310095018"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1683"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.5.883"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-6632.2000.tb06403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-6632.2000.tb06403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:51:43Z","timestamp":1695624703000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-6632.2000.tb06403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1111\/j.1749-6632.2000.tb06403.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb06403.x","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}