{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:49:50Z","timestamp":1767865790050,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T00:00:00Z","timestamp":1138147200000},"content-version":"vor","delay-in-days":1760,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> In the normal human life span, there occur lifestyle\u2010related diseases that may be preventable with nontoxic agents. This paper deals with the preventive activity of green tea in some lifestyle\u2010related diseases. Green tea is one of the most practical cancer preventives, as we have shown in various <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experiments, along with epidemiological studies. Among various biological effects of green tea, we have focused on its inhibitory effect on TNF\u2010\u03b1 gene expression mediated through inhibition of NF\u2010\u03baB and AP\u20101 activation. Based on our recent results with TNF\u2010\u03b1\u2010deficient mice, TNF\u2010\u03b1 is an endogenous tumor promoter. TNF\u2010\u03b1 is also known to be a central mediator in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis. We therefore hypothesized that green tea might be a preventive agent for chronic inflammatory diseases. To test this hypothesis, TNF\u2010\u03b1 transgenic mice, which overexpress TNF\u2010\u03b1 only in the lungs, were examined. The TNF\u2010\u03b1 transgenic mouse is an animal model of human idiopathic pulmonary fibrosis which also frequently develops lung cancer. Expressions of TNF\u2010\u03b1 and IL\u20106 were inhibited in the lungs of these mice after treatment with green tea in drinking water for 4 months. In addition, judging from the results of a prospective cohort study in Saitama Prefecture, Japan, green tea helps to prevent cardiovascular disease. In this study, a decreased relative risk of death from cardiovascular disease was found for people consuming over 10 cups of green tea a day, and green tea also had life\u2010prolonging effects on cumulative survival. These data suggest that green tea has preventive effects on both chronic inflammatory diseases and lifestyle\u2010related diseases (including cardiovascular disease and cancer), resulting in prolongation of life span.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2001.tb05656.x","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T00:40:43Z","timestamp":1279672843000},"page":"274-280","source":"Crossref","is-referenced-by-count":156,"title":["A New Function of Green Tea: Prevention of Lifestyle\u2010related Diseases"],"prefix":"10.1111","volume":"928","author":[{"given":"Naoko","family":"Sueoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Suganuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisaburo","family":"Sueoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazue","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Nakachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirota","family":"Fujiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650010110"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/42381"},{"key":"e_1_2_5_4_2","first-page":"236","article-title":"Clinical development plan: tea extracts green tea polyphenols epigallocatechin gallate","volume":"26","author":"NCI DCPC","year":"1996","journal-title":"J. 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S. Matsuyama S. Miyakeet al.2000. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors. 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