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APN in OPT may result from electrotonic coupling between neurons in the hypertrophied inferior olivary nucleus, which induces maladaptive learning in cerebellar cortex. We tested these two hypotheses by analyzing the effects of gabapentin, memantine, and baclofen on both forms of nystagmus. No drug changed the dominant frequency of either form of APN, but the variability of frequency was affected with gabapentin and memantine in patients with OPT. The amplitude of APN in both MS and OPT was reduced with gabapentin and memantine, but not baclofen. Analyzing the effects of drug therapies on ocular oscillations provides a novel approach to test models of nystagmus.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2011.06118.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T19:47:30Z","timestamp":1317152850000},"page":"320-326","source":"Crossref","is-referenced-by-count":42,"title":["Pharmacological tests of hypotheses for acquired pendular nystagmus"],"prefix":"10.1111","volume":"1233","author":[{"given":"Aasef G.","family":"Shaikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Thurtell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance M.","family":"Optican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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