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Displaying INS\u2010like spontaneous eye oscillations, achiasmatic zebrafish\u2002<jats:italic>belladonna<\/jats:italic>\u2002(<jats:italic>bel<\/jats:italic>) mutants may provide new insights into the mystery of INS. In this study, we demonstrate that these spontaneous eye oscillations match the diagnostic waveforms of INS. As a result, zebrafish\u2002<jats:italic>bel<\/jats:italic>\u2002mutants can be used as an animal model for the study of INS. In zebrafish\u2002<jats:italic>bel<\/jats:italic>\u2002mutants, visual pathway abnormalities may contribute to the spontaneous nystagmus via an inverted signal to the pretectal area. We hypothesized that human INS may also be linked to visual pathway abnormalities (possibly underdiagnosed in INS patients) in a similar way.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2011.06150.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T19:47:30Z","timestamp":1317152850000},"page":"285-291","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans"],"prefix":"10.1111","volume":"1233","author":[{"given":"Melody","family":"Ying\u2010Yu Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieng\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina P.","family":"Huber\u2010Reggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan C.F.","family":"Neuhauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Straumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"508","volume-title":"Binocular Vision and Ocular Motility","author":"Noorden G.K.V.","year":"2002"},{"key":"e_1_2_7_3_2","unstructured":"CEMAS Working Group.2001.The National Eye Institute Publications.National Institutes of Health National Eye Institute. 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