{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:10:39Z","timestamp":1772550639534,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T00:00:00Z","timestamp":1316736000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>A significant number of patients with bilateral vestibulopathy suffer from cerebellar ataxia and central vestibular symptoms and vice versa. We examined 31 patients presenting with the combination of gait and stance ataxia, cerebellar ocular motor signs, and a bilaterally pathological head\u2010impulse test (HIT). Tests included neuro\u2010orthoptical examination, electromyography and neurography, caloric irrigation, pure\u2010tone audiogram, vestibular\u2010evoked myogenic potentials, and volumetric magnetic resonance imaging (MRI). Only 17 of 31 patients had a pathological caloric irrigation. Twenty\u2010three patients had evidence of polyneuropathy (predominantly mixed sensorimotor involving axonal loss and demyelination) and twenty of hypoacusis (1 unilateral and 19 bilateral). Voxel\u2010based morphometry comparing local gray matter brain volume between patients and controls revealed cerebellar atrophy involving both the vermis and the hemispheres. We conclude that there is a clinically relevant combination of cerebellar ataxia with cerebellar atrophy, bilaterally pathological HIT, polyneuropathy, and hypoacusis. This multisensory syndrome is most likely caused by a neurodegenerative disorder affecting different systems, leading to severe impairment of affected patients.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2011.06175.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T19:47:30Z","timestamp":1317152850000},"page":"127-138","source":"Crossref","is-referenced-by-count":57,"title":["Clinical, electrophysiological, and MRI findings in patients with cerebellar ataxia and a bilaterally pathological head\u2010impulse test"],"prefix":"10.1111","volume":"1233","author":[{"given":"Hanni","family":"Kirchner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olympia","family":"Kremmyda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"H\u00fcfner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Zingler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,23]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21105"},{"issue":"1","key":"e_1_2_8_3_2","first-page":"1","article-title":"The neck\u2010eye reflex in patients with reduced vestibular and optokinetic function","volume":"114","author":"Bronstein A.M.","year":"1991","journal-title":"Brain."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh030"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050225"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318210b719"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0887-6"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1007"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0459"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/VES-2000-10104","article-title":"Measurement of vestibular ocular reflex (VOR) time constants with a caloric step stimulus","volume":"10","author":"Formby C.","year":"2000","journal-title":"J. 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