{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:40:59Z","timestamp":1791182459641,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:italic>Mycoplasma genitalium<\/jats:italic> is the smallest microrganism capable of self\u2010replication. With its small genome, <jats:italic>M. genitalium<\/jats:italic> is the best representative of a minimal cell. The comparison of genome evolution among the three urogenital mycoplasmas, <jats:italic>M. genitalium<\/jats:italic>, <jats:italic>M. hominis,<\/jats:italic> and <jats:italic>Ureaplasma parvum,<\/jats:italic> not only indicated that they share a core genome of \u223c250 protein\u2010encoding genes that correspond to their basic cell metabolism, but also showed a striking difference in their energy\u2010generating pathways. <jats:italic>M. genitalium<\/jats:italic> is a sexually transmitted organism associated with nongonococcal urethritis in men and several inflammatory reproductive tract syndromes in women, such as cervicitis, pelvic inflammatory disease, and infertility. The treatment of <jats:italic>M. genitalium<\/jats:italic> infections has not yet been standardized. Macrolides are recommended, especially single\u2010dose azithromycin; tetracyclines are responsible for a large number of therapeutic failures without any acquired resistance demonstrated. Acquired resistance to macrolides and fluoroquinolones leading to therapeutic failure has been described.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2011.06418.x","type":"journal-article","created":{"date-parts":[[2012,3,9]],"date-time":"2012-03-09T02:34:40Z","timestamp":1331260480000},"source":"Crossref","is-referenced-by-count":20,"title":["The evolution of <i>Mycoplasma genitalium<\/i>"],"prefix":"10.1111","volume":"1230","author":[{"given":"Alain","family":"Blanchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"B\u00e9b\u00e9ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92461-2"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.1.46-50.1991"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.397"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.07.005"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201000020"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201000076"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151721"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190719"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000677"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.09.007"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00923.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir702"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1451-1455.2002"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001324"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/656739"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.030486"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/594123"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07848-0"},{"key":"e_1_2_8_21_2","first-page":"519","volume-title":"Antibiogram","author":"B\u00e9b\u00e9ar C.","year":"2010"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.027375"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/599033"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq074"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02027.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1207.051558"},{"key":"e_1_2_8_27_2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1086\/593188","article-title":"Azithromycin treatment failure in Mycoplasma genitalium\u2010positive patients with nongonococcal urethritis is associated with induced macrolide resistance","volume":"47","author":"Jensen J.S.","journal-title":"Clin. 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