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Nonsense mutations once again have become the target of readthrough compounds. In this brief review, we trace the development in our laboratory of the next generation of readthrough agents, small molecule readthrough (SMRT) drug\u2010like chemicals, and assays for comparing their<jats:italic>in vitro<\/jats:italic>activity. Possible mechanisms of action and potential clinical applications are considered.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06467.x","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T22:53:51Z","timestamp":1330124031000},"page":"33-40","source":"Crossref","is-referenced-by-count":23,"title":["SMRT compounds correct nonsense mutations in primary immunodeficiency and other genetic models"],"prefix":"10.1111","volume":"1250","author":[{"given":"Richard A.","family":"Gatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10295"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608616104"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21632"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.3.487"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.53.3.639"},{"key":"e_1_2_9_7_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0026-895X(25)14722-6","article-title":"Misreading of RNA codewords induced by aminoglycoside antibiotics","volume":"1","author":"Davies J.","year":"1965","journal-title":"Mol. 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