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PPs are also widely recognized by botanical dermatology as major plant constituents inducing allergic reactions, contact dermatitis, phytodermatoses, and photophytodermatoses. Notwithstanding these clinical observations, thousands of cosmetic\/dermatological preparations based on PP\u2010containing plant extracts or pure PPs emerge yearly with the claims of photoprotection, chemoprevention of skin tumors, anti\u2010aging, wound healing, etc. However, because of their peculiar physical, chemical, and biological properties, PPs could be a double\u2010edged sword for human skin, exerting both protective and damaging actions. Here, we distinguish direct and indirect anti\u2010 and pro\u2010oxidant properties of PPs, their interactions with major xenobiotic metabolic systems and sensors\/receptors of environmental hazards, anti\u2010 and proinflammatory potential, and photoprotection versus photosensitization.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06510.x","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T17:58:54Z","timestamp":1341338334000},"page":"77-86","source":"Crossref","is-referenced-by-count":45,"title":["Plant polyphenols and human skin: friends or foes"],"prefix":"10.1111","volume":"1259","author":[{"given":"Liudmila","family":"Korkina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955711796575489"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.12.044"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.5.585"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ04003X"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.284S"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00876.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.02.009"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00277.x"},{"key":"e_1_2_7_10_2","first-page":"15","article-title":"Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health","volume":"53","author":"Korkina L.","year":"2007","journal-title":"Cell. 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