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Of over a dozen alveolar cldns, cldn\u20103, cldn\u20104, and cldn\u201018 are the most highly expressed; other prominent alveolar claudins include cldn\u20105 and cldn\u20107. Cldn\u20103 is primarily expressed by type II alveolar epithelial cells, whereas cldn\u20104 and cldn\u201018 are expressed throughout the alveolar epithelium. Lung diseases associated with pulmonary edema, such as alcoholic lung syndrome and acute lung injury, affect alveolar claudin expression, which is frequently associated with impaired fluid clearance due to increased alveolar leak. However, recent studies have identified a role for increased cldn\u20104 in protecting alveolar barrier function following injury. 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