{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:10:05Z","timestamp":1776485405643,"version":"3.51.2"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>To investigate the regulation of tight junction molecules in normal human pancreatic duct epithelial (HPDE) cells and pancreatic cancer cells, we introduced the human telomerase reverse transcriptase (hTERT) gene into HPDE cells in primary culture and compared them to pancreatic cancer cell lines. The hTERT\u2010transfected HPDE cells were positive for PDE markers and expressed claudin\u20101, claudin\u20104, claudin\u20107, and claudin\u201018, occludin, tricellulin, marvelD3, JAM\u2010A, zonula occludens (ZO)\u20101, and ZO\u20102. The tight junction molecules, including claudin\u20104 and claudin\u201018 of normal HPDE cells, were in part regulated via a protein kinase C signal pathway by transcriptional control. In addition, claudin\u201018 in normal HPDE cells and pancreatic cancer cells was markedly induced by a PKC activator, and claudin\u201018 in pancreatic cancer cells was also modified by DNA methylation. In the marvel family of normal HPDE cells and pancreatic cancer cells, tricellulin was upregulated via a c\u2010Jun N\u2010terminal kinase pathway, and marvelD3 was downregulated during Snail\u2010induced epithelial\u2013mesenchymal transition.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06579.x","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T21:27:16Z","timestamp":1339018036000},"page":"85-92","source":"Crossref","is-referenced-by-count":23,"title":["Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells"],"prefix":"10.1111","volume":"1257","author":[{"given":"Takashi","family":"Kojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimasa","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_10_3_2","first-page":"6265","article-title":"Claudin\u20104 expression decreases invasiveness and metastatic potential of pancreatic cancer","volume":"63","author":"Michl P.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815701f3"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1631"},{"key":"e_1_2_10_6_2","first-page":"L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger E.E","year":"1992","journal-title":"Am. J. Physiol."},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04382.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.60.1.161"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1055"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00558.2003"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35067088"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-003-0219-y"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200510043"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.08.018"},{"key":"e_1_2_10_15_2","first-page":"1463","article-title":"Tight junction proteins and signal transduction pathways in hepatocytes","volume":"24","author":"Kojima T.","year":"2009","journal-title":"Histol. Histopathol."},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05654"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040104.131404"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01744-0"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27124"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1547"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01239.x"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26652"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.058412"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(02)02229-6"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-10-95"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E09-08-0734"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091226"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22273"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23095"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1287-2"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.06.020"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.349"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70109-5"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0453-z"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.2.293"},{"key":"e_1_2_10_36_2","first-page":"222","article-title":"Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms","volume":"38","author":"Andreeva A.Y.","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"e_1_2_10_37_2","first-page":"F293","article-title":"Cellular variability in the development of tight junctions after activation of protein kinase C","volume":"263","author":"Ellis B.","year":"1992","journal-title":"Am. J. Physiol."},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025524323842"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201427"},{"key":"e_1_2_10_40_2","first-page":"1417","article-title":"Ets transcription factors in intestinal morphogenesis, homeostasis and disease","volume":"23","author":"Jedlicka P.","year":"2008","journal-title":"Histol. Histopathol."},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608389200"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00328.2007"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.07.006"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31815ceaf7"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206199"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl120"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008002"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-05-0530"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E09-01-0080"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-009-0470-y"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.09.024"},{"key":"e_1_2_10_52_2","first-page":"2110","article-title":"c\u2010Jun N\u2010terminal kinase mediates disassembly of apical junctions in model intestinal epithelia","volume":"8","author":"Naydenov N.G.","journal-title":"2009"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-117804"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00084.2009"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm757"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000034"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000025"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00389"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.4.1031"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00052.2005"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1159\/000278293"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2926"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn216"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-08-0767"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01631.x"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2979"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.126"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-6632.2012.06579.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-6632.2012.06579.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:27:44Z","timestamp":1695684464000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-6632.2012.06579.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1749-6632.2012.06579.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06579.x","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}