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Previous studies have shown that T helper\u2013directed cellular immunity is suppressed in hypercortisolemic HIV patients, while it is activated in cortisol\u2010resistant HIV patients. This is suggestive of a cytokine system intimately linked with cortisol and its receptors. Highly active antiretroviral therapy is an important advance in the treatment of HIV infection, but the suppression of viral replication is not associated with reconstitution of the immune function. This would account for reduced control of inflammation and the activation of 11\u03b2\u2010hydroxysteroid dehydrogenase type 1(11\u03b2\u2010HSD1) and increases in glucocorticoid and mineralocorticoid production in peripheral tissues. Such hormonal activation may cause insulin resistance and cardiometabolic complications. Therapeutic approaches with 11\u03b2\u2010HSD1 inhibitors, aldosterone antagonists, type 1 angiotensin receptor blockers, or renin inhibitors are suggested.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06620.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T16:23:11Z","timestamp":1343060591000},"page":"51-55","source":"Crossref","is-referenced-by-count":16,"title":["Endocrine, metabolic, and immunologic components of HIV infection"],"prefix":"10.1111","volume":"1262","author":[{"given":"Guido","family":"Norbiato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"147","article-title":"Vigorous HIV\u20101 specific cd4+T\u2010cell response associated with control of viremia","volume":"278","author":"Rosemberg E.S.","year":"1997","journal-title":"Science"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001280-00005"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-17-3-245"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.005"},{"key":"e_1_2_10_6_2","volume-title":"Baillier Tindall. 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