{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:35:28Z","timestamp":1762101328866},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T00:00:00Z","timestamp":1343001600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:italic>Trypanosoma cruzi<\/jats:italic> infection in mice triggers neuroendocrine responses that affect the course of the disease. To analyze the contribution of adaptive immunity to these responses, comparative studies between normal C57Bl\/6J and recombinase activator gene 1 (RAG\u20101)\u2013deficient mice, which lack mature B and T lymphocytes, were performed. There was no difference between both types of mice in basal body weight. Following infection, higher parasitemia, increased IL\u20101\u03b2 and IL\u20106 blood levels, less marked changes in lymphoid organs weight, no cardiomegaly, and earlier mortality were observed in RAG\u20101\u2013deficient, compared with normal mice. The response of the hypothalamus\u2013pituitary\u2013adrenal axis after infection occurred earlier and was more intense in RAG\u20101\u2013deficient mice than in normal mice. Noradrenaline concentration and serotonergic metabolism in the spleen, lymph nodes, and heart differed between RAG\u20101\u2013deficient and normal mice. Our studies indicate that the absence of adaptive immunity to <jats:italic>T. cruzi<\/jats:italic> influences the neuroendocrine response to the infection with this parasite.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06645.x","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T16:23:11Z","timestamp":1343060591000},"page":"37-44","source":"Crossref","is-referenced-by-count":5,"title":["Different peripheral neuroendocrine responses to <i>Trypanosoma cruzi<\/i> infection in mice lacking adaptive immunity"],"prefix":"10.1111","volume":"1262","author":[{"given":"Eduardo","family":"Roggero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Wildmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo 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