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DES is a common disorder affecting an estimated 25\u201330 million people in the United States alone and is characterized by inflammation of the ocular surface. Consequently, patients can suffer from burning, irritation, severe discomfort, foreign body sensation, and blurry and decreased vision. Recent animal studies of DES demonstrate that T\u03b24 eye drops significantly reduce corneal fluorescein staining, indicating improved wound healing. Based on previous studies, there is clear support for further clinical investigation and development of T\u03b24 as a novel, safe, and effective agent to treat dry eye. Herein, we discuss the scientific and clinical rationales that make T\u03b24 a potential ideal candidate therapeutic for DES.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06682.x","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T10:45:14Z","timestamp":1349952314000},"page":"45-50","source":"Crossref","is-referenced-by-count":22,"title":["Thymosin \u03b24: a potential novel dry eye therapy"],"prefix":"10.1111","volume":"1270","author":[{"given":"Gabriel","family":"Sosne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Ousler 3rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Crockford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71688-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00462-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.10.036"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2417-5_83"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1983.tb01401.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(89)90657-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)33986-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2417-5_66"},{"key":"e_1_2_5_10_2","first-page":"216","article-title":"Effect of punctal occlusion by Freeman silicone plug insertion on tear osmolarity in dry eye disorders","volume":"15","author":"Gilbard J.P.","year":"1989","journal-title":"CLAO J."},{"key":"e_1_2_5_11_2","first-page":"1783","article-title":"High\u2010speed videotopographic measurement of tear film build\u2010up time","volume":"43","author":"Nemeth J.","year":"2002","journal-title":"Invest. 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