{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:52:49Z","timestamp":1782755569354,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Thymosin \u03b24 (T\u03b24) plays a role in fibrosis, inflammation, and in the reparative process of injured cells and tissues. Here, we discuss our preliminary work on the protective effect of T\u03b24 on carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )\u2010induced acute hepatotoxicity. Our studies thus far indicate that T\u03b24 can prevent necrosis, inflammatory infiltration, and upregulation of \u03b11(and 2) collagen, \u03b1\u2010SMA, PDGF\u2010\u03b2 receptor, and fibronectin mRNA expression; in addition, T\u03b24 can prevent downregulation of PPAR\u03b3 and upregulation of MECP2 mRNA levels in acute liver injury. Our initial work therefore indicates that T\u03b24 can prevent the alteration of markers of hepatic stellate cell transdifferentiation, which suggests that T\u03b24 could maintain the quiescent phenotypic state of hepatic stellate cells in the rat livers by restoring PPAR\u03b3 and downregulating MeCP2 expression levels. More specifically, these preliminary studies suggest that T\u03b24 might be an effective anti\u2010inflammatory and antifibrotic drug for the treatment of liver fibrogenesis.\n                  <\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06728.x","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T13:33:10Z","timestamp":1349789590000},"page":"61-68","source":"Crossref","is-referenced-by-count":23,"title":["Protective effects of thymosin \u03b24 on carbon tetrachloride\u2010induced acute hepatotoxicity in rats"],"prefix":"10.1111","volume":"1269","author":[{"given":"Karina","family":"Reyes\u2010Gordillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Arellanes\u2010Robledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Rojkind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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