{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:07:10Z","timestamp":1744178830643},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:italic>Aspergillus<\/jats:italic> species are responsible for most cases of fatal mold infections in immunocompromised patients, particularly in those receiving hematopoietic stem cell transplants. Experimental vaccines in mouse models have demonstrated a promising avenue of approach for the prevention of aspergillosis, as well as infections caused by other fungal pathogens, such as <jats:italic>Coccidioides<\/jats:italic>, the etiological agent of valley fever (coccidioidomycosis). Here, we investigated the hyphal proteomes of <jats:italic>Aspergillus fumigatus<\/jats:italic> and <jats:italic>Coccidioides posadasii<\/jats:italic> via quantitative MS<jats:sup>E<\/jats:sup> mass spectrometry with the objective of developing a vaccine that cross\u2010protects against these and other species of fungi. Several homologous proteins with highly conserved sequences were identified and quantified in <jats:italic>A. fumigatus<\/jats:italic> and <jats:italic>C. posadasii<\/jats:italic>. Many abundant proteins from the cell wall of <jats:italic>A. fumigatus<\/jats:italic> present themselves as possible cross\u2010protective vaccine candidates, due to the high degree of sequence homology to other medically relevant fungal proteins and low homologies to human or murine proteins.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06761.x","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T15:26:16Z","timestamp":1355239576000},"page":"44-51","source":"Crossref","is-referenced-by-count":19,"title":["Protein targets for broad\u2010spectrum mycosis vaccines: quantitative proteomic analysis of <i>Aspergillus<\/i> and <i>Coccidioides<\/i> and comparisons with other fungal pathogens"],"prefix":"10.1111","volume":"1273","author":[{"given":"Jackson","family":"Champer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Diaz\u2010Arevalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Champer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa B.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayyen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Shannahoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James I.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl V.","family":"Clemons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kalkum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.1.44-69.2005"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(08)70009-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2007.01.013"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(98)90303-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.48.1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780600919262"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.804-839.2004"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020002"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00055-08"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2009.09.002"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767130-00001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.06.002"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00815-06"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01311-10"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1865-1872.2006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.516-527.2006"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-325084"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.033290-0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.497775"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.03.030"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2012.692418"},{"key":"e_1_2_7_23_2","unstructured":"Majumder T. 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