{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:56:16Z","timestamp":1773788176967,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>In myasthenia gravis (MG) and experimental autoimmune MG (EAMG), many pathologically significant autoantibodies are directed to the main immunogenic region (MIR) of muscle nicotinic acetylcholine receptors (AChRs), a conformation\u2010dependent region at the extracellular tip of \u03b11 subunits of AChRs. Human muscle AChR \u03b11 MIR sequences were integrated into <jats:italic>Aplesia<\/jats:italic> ACh\u2010binding protein (AChBP). The chimera potently induced EAMG, while AChBP induced EAMG much less potently. AChBP is a water\u2010soluble protein resembling the extracellular domain of AChRs; yet, rats immunized with chimeras developed autoantibodies to both extracellular and cytoplasmic domains of muscle AChRs. We propose that an initial autoimmune response directed at the MIR leads to an autoimmune response sustained by muscle AChRs. Autoimmune stimulation sustained by endogenous muscle AChR may be a target for specific immunosuppression. These studies show that the \u03b11 MIR is highly myasthenogenic, and that AChR\u2010like proteins distantly related to muscle AChR can induce EAMG and, potentially, MG.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06766.x","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T19:02:49Z","timestamp":1355857369000},"page":"9-13","source":"Crossref","is-referenced-by-count":12,"title":["Myasthenogenicity of the main immunogenic region"],"prefix":"10.1111","volume":"1274","author":[{"given":"Jon","family":"Lindstrom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.755"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200004)23:4<453::AID-MUS3>3.0.CO;2-O"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2833-09.2009"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.12.031"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077011"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600828"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01252.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nn1942","article-title":"Crystal structure of the extracellular domain of nAChR \u03b11 bound to \u03b1bungarotoxin at 1.94 \u00c5 resolution","volume":"10","author":"Delisanti C.","year":"2007","journal-title":"Nature Neurosci."},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707661"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05924.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-009-9229-0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.2.769"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.622015"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(03)00209-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb47691.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21901"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.03.017"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-6632.2012.06766.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-6632.2012.06766.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:18:24Z","timestamp":1695017904000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-6632.2012.06766.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1749-6632.2012.06766.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06766.x","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}