{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:25:54Z","timestamp":1787311554096,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    Aire (autoimmune regulator) has a key role in the establishment of tolerance to autoantigens. Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice present decreased thymic expression of AChR, significantly lower frequencies of regulatory T (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) cells, and higher expression of Th17 markers, compared to controls. We therefore predicted that Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice would be more susceptible to induction of experimental autoimmune myasthenia gravis (EAMG). However, when EAMG was induced in young mice, Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice presented a milder disease that wild\u2010type (WT) controls. In contrast, when EAMG was induced in older mice, Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were more severely affected than WT mice. The relative resistance to EAMG in young Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice correlated with increased numbers of T\n                    <jats:sub>reg<\/jats:sub>\n                    cells in their spleens compared to young controls. A similar age\u2010related susceptibility was also observed when EAE was induced in Aire\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, suggesting an age\u2010related link among Aire, disease susceptibility, and peripheral T\n                    <jats:sub>reg<\/jats:sub>\n                    cells that may be a general feature of autoimmunity.\n                  <\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06843.x","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T22:28:36Z","timestamp":1356128916000},"page":"107-113","source":"Crossref","is-referenced-by-count":10,"title":["Experimental myasthenia gravis in Aire\u2010deficient mice: a link between Aire and regulatory T cells"],"prefix":"10.1111","volume":"1275","author":[{"given":"Revital","family":"Aricha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Feferman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Berrih\u2010Aknin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam C.","family":"Souroujon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2450"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.07.005"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-333"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159407"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802124"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.1208"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.1862"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3900"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.03.016"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02220.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.04.005"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.03.011"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2132"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03442.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06066"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2141"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091669"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.09.007"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24501"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni906"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1444"},{"key":"e_1_2_8_24_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ni.1874","article-title":"Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance","volume":"11","author":"Hinterberger M.","journal-title":"Nat. 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