{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:37:34Z","timestamp":1769920654181,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Establishment of tolerance in myasthenia gravis (MG) involves regulatory T (T<jats:sub>reg<\/jats:sub>) cells. Experimental autoimmune MG (EAMG) in rats is a suitable model for assessing the contribution of T<jats:sub>reg<\/jats:sub> cells to the immunopathology of the disease and for testing novel T<jats:sub>reg<\/jats:sub> cell\u2013based treatment modalities. We have studied two immunotherapeutic approaches for targeting of T<jats:sub>reg<\/jats:sub> cells in myasthenia. By one approach we demonstrated that treatment of sick rats by <jats:italic>ex vivo<\/jats:italic>\u2013generated exogenous T<jats:sub>reg<\/jats:sub> cells derived from healthy donors suppressed EAMG. By a different approach, we aimed at affecting the endogenous T<jats:sub>reg<\/jats:sub>\/Th17 cell balance by targeting IL\u20106, which has a key role in controlling the equilibrium between pathogenic Th17 and suppressive T<jats:sub>reg<\/jats:sub> cells. We found that treatment of myasthenic rats by neutralizing anti\u2010IL\u20106 antibodies shifted this equilibrium in favor of T<jats:sub>reg<\/jats:sub> cells and led to suppression of EAMG. Our results show that T<jats:sub>reg<\/jats:sub> cells could serve as potential targets in treating MG patients.<\/jats:p>","DOI":"10.1111\/j.1749-6632.2012.06844.x","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T19:02:49Z","timestamp":1355857369000},"page":"120-126","source":"Crossref","is-referenced-by-count":10,"title":["Regulatory T cell\u2013based immunotherapies in experimental autoimmune myasthenia gravis"],"prefix":"10.1111","volume":"1274","author":[{"given":"Miriam C.","family":"Souroujon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revital","family":"Aricha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Feferman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Mizrachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debby","family":"Reuveni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/83784"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2889"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3900"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.03.016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02220.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.04.005"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2622"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03173.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901163"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2132"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.12.001"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903518081"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri821"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.12.003"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324725"},{"key":"e_1_2_5_18_2","first-page":"1184","article-title":"Transplantation tolerance mediated by regulatory T cells in mice","volume":"117","author":"Feng N.H.","year":"2004","journal-title":"Chin. Med. J."},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh368"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2008.01.001"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.007"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00027-8"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb22873.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01079.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.001345"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-79275-5_23"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-215-44119"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809850105"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1749-6632.2012.06844.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1749-6632.2012.06844.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:18:13Z","timestamp":1695017893000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1749-6632.2012.06844.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1749-6632.2012.06844.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1749-6632.2012.06844.x","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}