{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:49:42Z","timestamp":1772160582218,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T00:00:00Z","timestamp":1317254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>\n                    <jats:italic>Please cite this paper as:<\/jats:italic>\n                    Wang\n                    <jats:italic>et\u00a0al.<\/jats:italic>\n                    (2011) No evidence of a link between influenza vaccines and Guillain\u2013Barre syndrome\u2013associated antiganglioside antibodies. Influenza and Other Respiratory Viruses 6(3), 159\u2013166.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Guillain\u2013Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside antibodies are subsequently induced remains unresolved.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Sera from human subjects vaccinated with seasonal influenza vaccines from the 2007\u20132008, 2008\u20132009, or 1976\u20131977 influenza seasons were screened for the induction of immunity to influenza and the presence of antiganglioside antibodies pre\u2010 and post\u2010vaccination. Likewise, sera from mice vaccinated with seasonal influenza vaccines (1988\u20131989, 2007\u20132008) or \u201cswine flu\u201d pandemic vaccines (1976, 2009) were assessed in the same manner. Viruses were also screened for cross\u2010reacting ganglioside epitopes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Antiganglioside antibodies were found to recognize influenza viruses; this reactivity correlated with virus glycosylation. Antibodies to influenza viruses were detected in human and mouse sera, but the prevalence of antiganglioside antibodies was extremely low.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    Although the correlation between antiganglioside antibody cross\u2010reactivity and glycosylation of viruses suggests the role of shared carbohydrate epitopes, no correlation was observed between hemagglutinin\u2010inhibition titers and the induction of antiganglioside antibodies after influenza vaccination.\n                  <\/jats:p>","DOI":"10.1111\/j.1750-2659.2011.00294.x","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T02:30:39Z","timestamp":1317263439000},"page":"159-166","source":"Crossref","is-referenced-by-count":13,"title":["No evidence of a link between influenza vaccines and Guillain\u2013Barre syndrome\u2013associated antiganglioside antibodies"],"prefix":"10.1111","volume":"6","author":[{"given":"David J.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Boltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"McElhaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"McCullers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Webby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/603560"},{"key":"e_1_2_8_3_2","first-page":"199","article-title":"Guillain\u2010Barre syndrome and vaccination: usually unrelated","volume":"36","author":"Grabenstein JD","year":"2001","journal-title":"Hosp Pharm"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.08.033"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00967-06"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.053"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.12.004"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.01.125"},{"key":"e_1_2_8_9_2","unstructured":"AgencyEM.Twentieth pandemic pharmacovigilance update.2010. Available athttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Report\/2010\/06\/WC500093182.pdf(Accessed 15 December 2010)."},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/oxfordjournals.aje.a113810","article-title":"Guillain\u2010Barre syndrome and its relationship to swine influenza vaccination in Michigan, 1976\u20131977","volume":"119","author":"Breman JG","year":"1984","journal-title":"Am J Epidemiol"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03300500016019"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115973"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112795"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.20.2478"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198106253042601"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.20.2217"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.5.633"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115974"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn310"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20395"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwp027"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.237"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70140-7"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/589624"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/652441"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1999.610071.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-006-5443-y"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-5"},{"key":"e_1_2_8_29_2","unstructured":"CDC.General questions and answers on Guillain\u2010Barre syndrome (GBS).2009."},{"key":"e_1_2_8_30_2","first-page":"223","article-title":"A single\u2010radial\u2010immunodiffusion technique for the assay of influenza haemagglutinin antigen. Proposals for an assay method for the haemagglutinin content of influenza vaccines","volume":"52","author":"Schild GC","year":"1975","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-1157(77)80008-5"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.001"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.09.013"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00580-9"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39374-3"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(78)90200-X"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200009)23:9<1414::AID-MUS13>3.0.CO;2-0"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.08.021"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2010.05.008"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.08.024"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-596"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/2211255a0"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.09.021"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008553"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1750-2659.2011.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1750-2659.2011.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T03:37:13Z","timestamp":1698637033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1750-2659.2011.00294.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,29]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1750-2659.2011.00294.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1750-2659.2011.00294.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13377011.14747122","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,29]]}}}