{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:30:20Z","timestamp":1793223020514,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T00:00:00Z","timestamp":1170979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                    <jats:bold>ABSTRACT:\u2002<\/jats:bold>\n                    The increase of multidrug\u2010resistant pathogens of human and animal origins is a major public health concern. For a better understanding of the health consequences of multidrug\u2010resistant bacteria transmitted from animal products to humans, the host interaction of zoonotic\n                    <jats:italic>Salmonella<\/jats:italic>\n                    isolates along with other pathogenic and commensal bacteria was evaluated using a human intestinal Caco\u20102 cell system. Multidrug\u2010resistant\n                    <jats:italic>S<\/jats:italic>\n                    . Agona,\n                    <jats:italic>S<\/jats:italic>\n                    . Heidelberg, and\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium possessed plasmid\u2010mediated class 1 integrons. The\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium DT104 isolate from ground beef showed the well\u2010known genotypic and phenotypic resistance characteristics of the species, and contained the chromosomally located class 1 integron. Among the multidrug\u2010resistant\n                    <jats:italic>Salmonella<\/jats:italic>\n                    isolates, the\n                    <jats:italic>S<\/jats:italic>\n                    . Heidelberg 219 had the highest invasion number at 1.0 \u00d7 10\n                    <jats:sup>4<\/jats:sup>\n                    CFU\/mL, followed by the\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium DT104 isolate at 7.7 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    CFU\/mL.\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    was the best performer among the tested species in invading the Caco\u20102 cell. Multidrug\u2010resistant opportunistic pathogens\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    were also able to invade the cells. The invasion of\n                    <jats:italic>S<\/jats:italic>\n                    . Heidelberg 219,\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium DT104,\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    ,\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    , and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    into the Caco\u20102 cells was not affected even in the presence of commensal\n                    <jats:italic>E. coli<\/jats:italic>\n                    . During the intracellular growth of\n                    <jats:italic>S<\/jats:italic>\n                    . Heidelberg 219,\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium DT104, and\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    , the bacterial counts increased 2 log cycles in 9 h in the Caco\u20102 cells. Therefore, these strains could rapidly proliferate after their invasion into the cells.\n                  <\/jats:p>","DOI":"10.1111\/j.1750-3841.2006.00268.x","type":"journal-article","created":{"date-parts":[[2007,2,10]],"date-time":"2007-02-10T06:17:01Z","timestamp":1171088221000},"source":"Crossref","is-referenced-by-count":9,"title":["Invasiveness and Intracellular Growth of Multidrug\u2010Resistant\n                    <i>Salmonella<\/i>\n                    and Other Pathogens in Caco\u20102 Cells"],"prefix":"10.1111","volume":"72","author":[{"given":"S.\u2010H.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010I.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4673-4677.2001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-6-503"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5725-5732.2001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.846"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008633"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1999.0322"},{"key":"e_1_2_5_8_1","first-page":"701","article-title":"Outbreaks of multidrug\u2010resistant Salmonella Typhimurium associated with veterinary facilities\u2014Idaho, Minnesota, and Washington, 1999","volume":"50","author":"CDC","year":"2001","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.1.1-7.2004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4279-4284.2003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-50-9-759"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4466-4469.2004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.4315\/0362-028X-64.11.1698","article-title":"Colonization of broiler chicks by Salmonella Typhimurium Definitive phage type 104","volume":"64","author":"Fedorka PJ","year":"2001","journal-title":"J Food Prot"},{"key":"e_1_2_5_14_1","first-page":"17","volume-title":"FDA bacteriological analytical manual","author":"Food and Drug Administration","year":"1992"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/514909"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.037382"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0805.010267"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1128\/jcm.34.4.908-911.1996","article-title":"Detection of extended\u2010spectrum beta\u2010lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli","volume":"34","author":"Jacoby CA","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1520-1525.2004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb08921.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-68.10.2022"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-68.12.2527"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.11.5698-5703.2002"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.4035-4037.2002"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.1.128"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.185"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1124S"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.647-679.2002"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0505.990502"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0804.010213"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4668-4675.2005"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2321"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.07.004"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200400035"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00066-4"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.134.22.577"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/340251"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3924"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1105.041042"},{"key":"e_1_2_5_40_1","volume-title":"Intl. 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