{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:45:16Z","timestamp":1783950316762,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2012,1]]},"abstract":"\n Abstract:\u2003<\/jats:bold>\n Lactobacilli have positive effects on bowel microflora and health in humans and animals. In this study, the antagonistic activities of\n Lactobacillus gasseri<\/jats:italic>\n Chen, and\n L. plantarum<\/jats:italic>\n 18 were assessed by agar plate diffusion assay and tests that determined the growth and urease activity of\n Helicobacter pylori<\/jats:italic>\n cocultured with lactobacilli and the adherence of\n H. pylori<\/jats:italic>\n to human gastric epithelial cells in the presence of lactobacilli. The results showed that the 2\n Lactobacillus<\/jats:italic>\n strains had significant anti\u2010\n H.pylori<\/jats:italic>\n activity, and this activity may be contributed by the cell\u2010free supernatants (CFS) of lactobacilli and live\n Lactobacillus<\/jats:italic>\n strains\n in vitro<\/jats:italic>\n . The antagonistic activity of the CFS against\n H. pylori<\/jats:italic>\n depended on the pH and the presence of metabolites, such as organic acids and proteases. Our results also indicated that 2\n Lactobacillus<\/jats:italic>\n strains could inhibit\n H. pylori<\/jats:italic>\n adherence human gastric epithelial cells.\n <\/jats:p>\n \n Practical Application:\u2003<\/jats:bold>\n Helicobacter pylori<\/jats:italic>\n causes chronic gastritis, peptic ulcer disease, and gastric cancer, and it infects about 50% of the world's population. Lactobacilli have been reported to have an inhibitory effect on\n H. pylori<\/jats:italic>\n and can be used as probiotic to manufacture dairy products preventing\n H. pylori<\/jats:italic>\n infection.\n <\/jats:p>","DOI":"10.1111\/j.1750-3841.2011.02498.x","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:52:31Z","timestamp":1324302751000},"source":"Crossref","is-referenced-by-count":46,"title":["Antagonistic Activities of Lactobacilli against\n Helicobacter pylori<\/i>\n Growth and Infection in Human Gastric Epithelial Cells"],"prefix":"10.1111","volume":"77","author":[{"given":"Xiaohua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u2010ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00600.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00923.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00666-06"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.425-434.2006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.4.483"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-3449"},{"issue":"5","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/AAC.41.5.1046","article-title":"Antibacterial 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