{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:00:37Z","timestamp":1778072437677,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2003<\/jats:bold>\n                    In the present study,\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidant, antioxidative stress and hepatoprotective activity of\n                    <jats:italic>Moringa oleifera<\/jats:italic>\n                    Lam. seed oil (Ben oil; BO) was evaluated against carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) induced lipid peroxidation and hepatic damage in rats. The oil at 0.2 and 0.4 mL\/rat was administered orally for 21 consecutive days. The substantially elevated serum enzymatic (GOT, GPT, ALP, GGT) and bilirubin levels were significantly restored towards normalization by the oil. There was a significant elevation in the level of malondialdehyde (MDA), non\u2010protein sulfhydryl (NP\u2010SH), and total protein (TP) contents in the liver tissue. The results obtained indicated that BO possesses potent hepatoprotective action against CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced hepatic damage by lowering liver marker enzymes, MDA concentration, and elevating NP\u2010SH and TP levels in liver tissue. The biochemical observations were supplemented with histopathological examination of rat liver. The results of this study showed that treatment with Ben oil or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    . The pentobarbital induced narcolepsy prolongation in mice was retarded by the Ben oil. Acute toxicity test in mice showed no morbidity or mortality.\n                    <jats:italic>In vitro<\/jats:italic>\n                    DPPH radical scavenging and \u03b2\u2010carotene\u2010linolic acid assay tests of the BO exhibited a moderate antioxidant activity in both tests used. The possible mechanism(s) of the liver protective activity of Ben oil activity may be due to free radical scavenging potential caused by the presence of antioxidant component(s) in the oil. Consequently, BO can be used as a therapeutic regime in treatment of some hepatic disorders.\n                  <\/jats:p>","DOI":"10.1111\/j.1750-3841.2012.02698.x","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T14:12:18Z","timestamp":1341324738000},"source":"Crossref","is-referenced-by-count":29,"title":["Edible Oils for Liver Protection: Hepatoprotective Potentiality of\n                    <i>Moringa Oleifera<\/i>\n                    Seed Oil against Chemical\u2010Induced Hepatitis in Rats"],"prefix":"10.1111","volume":"77","author":[{"given":"Mansour S.","family":"Al\u2010Said","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramzi A.","family":"Mothana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed 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