{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T09:35:13Z","timestamp":1725788113322},"reference-count":36,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T00:00:00Z","timestamp":1171411200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Infectious bovine keratoconjunctivitis (IBK) is one of the most common diseases of cattle and is of major economic importance. If the primary aetiological agent,<jats:italic>Moraxella bovis<\/jats:italic>, is successfully eliminated from ocular tissues corneal ulcers heal at a constant rate. If treatment is unsuccessful ulcer reoccurrence may follow initial healing. Appropriate antimicrobial selection requires knowledge of antimicrobial sensitivities and distribution in ocular tissues and tears. Drugs may be delivered to the eye in several ways: subconjunctival injection, topical application and systemic administration. While therapeutic efficacy is affected by the frequency and mode of drug delivery, variations between intensive and extensive enterprises dictate the practical method of antimicrobial delivery. Specific recommendations for antimicrobial therapies targeting Australian IBK outbreaks are dependent upon antimicrobial pharmacokinetics, drug regulations and associated costs.<\/jats:p>","DOI":"10.1111\/j.1751-0813.2006.00080.x","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:33:17Z","timestamp":1171503197000},"page":"65-69","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Infectious bovine keratoconjunctivitis antimicrobial therapy"],"prefix":"10.1111","volume":"85","author":[{"given":"CS","family":"Mcconnel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Shum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JK","family":"House","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_10_2_2","unstructured":"BarnerRD.A study ofMoraxella bovisand its relation to bovine keratitis.Am J Vet Res 1952;132\u2013144."},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","unstructured":"BrownMH BrightmanAH FenwickBW et al.Infectious bovine keratoconjunctivitis: a review.J Vet Intern Med 1998;259\u201366.","DOI":"10.1111\/j.1939-1676.1998.tb02120.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"crossref","unstructured":"NagyA VandersmissenE KappP.Further data to the aetiology pathogenesis and therapy of infectious bovine keratoconjunctivitis.Comp Immunol Microbiol Infect Dis 1989;115\u201327.","DOI":"10.1016\/0147-9571(89)90060-X"},{"key":"e_1_2_10_5_2","doi-asserted-by":"crossref","unstructured":"SlatterDH EdwardsME HawkinsCD et al.A national survey of the occurrence of infectious bovine keratoconjunctivitis.Aust Vet J 1982;65\u20138.","DOI":"10.1111\/j.1751-0813.1982.tb02728.x"},{"key":"e_1_2_10_6_2","unstructured":"GeorgeLW.Antibiotic treatment of infectious bovine keratoconjunctivitis.Cornell Vet 1990;229\u201335."},{"key":"e_1_2_10_7_2","doi-asserted-by":"crossref","unstructured":"SlatterDH EdwardsME HawkinsCD et al.A national survey of the clinical features treatment and importance of infectious bovine keratoconjunctivitis.Aust Vet J 1982;69\u201372.","DOI":"10.1111\/j.1751-0813.1982.tb02729.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","unstructured":"AngelosJA DuegerEL GeorgeLW et al.Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis.J Am Vet Med Assoc 2000;62\u20134.","DOI":"10.2460\/javma.2000.216.62"},{"key":"e_1_2_10_9_2","unstructured":"GeorgeLW WilsonWD BaggotJD et al.Antibiotic treatment of Moraxella bovis infection in cattle.J Am Vet Med Assoc 1984;1206\u20139."},{"key":"e_1_2_10_10_2","unstructured":"GeorgeL MihalyiJ EdmondsonA et al.Topically applied furazolidone or parenterally administered oxytetracycline for the treatment of infectious bovine keratoconjunctivitis.J Am Vet Med Assoc 1988;1415\u201322."},{"key":"e_1_2_10_11_2","doi-asserted-by":"crossref","unstructured":"DaigneaultJ GeorgeLW.Topically applied benzathine cloxacillin for treatment of experimentally induced infectious bovine keratoconjunctivitis.Am J Vet Res 1990;376\u201380.","DOI":"10.2460\/ajvr.1990.51.03.376"},{"key":"e_1_2_10_12_2","doi-asserted-by":"crossref","unstructured":"WebberJJ FalesWH SelbyLA.Antimicrobial susceptibility of Moraxella bovis determined by agar disk diffusion and broth microdilution.Antimicrob Agents Chemother 1982;554\u20137.","DOI":"10.1128\/AAC.21.4.554"},{"key":"e_1_2_10_13_2","doi-asserted-by":"crossref","unstructured":"ShryockTR WhiteDW WernerCS.Antimicrobial susceptibility of Moraxella bovis.Vet Microbiol 1998;305\u20139.","DOI":"10.1016\/S0378-1135(98)00191-6"},{"key":"e_1_2_10_14_2","unstructured":"McConnelCS ShumL HouseJK.AustralianMoraxellaisolates\u2019 antimicrobial susceptibility.Aust Vet J 2006in press."},{"key":"e_1_2_10_15_2","doi-asserted-by":"crossref","unstructured":"WardDA ClarkSE.Ocular Pharmacology.Vet Clin North Am Large Anim Pract 1991;779\u2013791.","DOI":"10.1016\/S0749-0720(15)31084-7"},{"key":"e_1_2_10_16_2","doi-asserted-by":"crossref","unstructured":"AllenLJ GeorgeLW WillitsNH.Effect of penicillin or penicillin and dexamethasone in cattle with infectious bovine keratoconjunctivitis.J Am Vet Med Assoc 1995;1200\u20133.","DOI":"10.2460\/javma.1995.206.08.1200"},{"key":"e_1_2_10_17_2","doi-asserted-by":"crossref","unstructured":"AbeynayakeP CooperBS.The concentration of penicillin in bovine conjunctival sac fluid as it pertains to the treatment of Moraxella bovis infection. 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