{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:35:56Z","timestamp":1761597356871},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust Veterinary J"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Background\u2003<\/jats:bold> The occurrence of <jats:italic>Tribulus terrestris<\/jats:italic> motor neurone disease (MND) in sheep is linked with grazing <jats:italic>Tribulus<\/jats:italic> growing on cultivation paddocks. A previous survey found that the molybdenum (Mo) content of <jats:italic>Tribulus<\/jats:italic> growing on uncultivated soils in the Coonabarabran district of New South Wales was 3.03\u2003ppm, but on cultivated soils it was &lt;0.04\u2003ppm. <jats:italic>Tribulus<\/jats:italic> contains the purine, xanthosine, which functions as a neuromodulator, and the catabolism of xanthosine is Mo\u2010dependent.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> To investigate the relationship between xanthosine ingestion and low Mo concentration, eight sheep were fed Mo\u2010deficient lucerne chaff (&lt;0.10\u2003ppm), the Mo antagonist, sodium tungstate, and xanthosine (25\u2003mg\/kg\/day) over 18 weeks and then returned to pasture.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Signs of MND developed in two sheep 30 months later and astrocyte degeneration occurred in all sheep.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> The findings were similar to those observed in sheep with <jats:italic>T. terrestris<\/jats:italic> MND, suggesting that the combination of xanthosine ingestion and Mo deficiency may be the cause of this disorder.<\/jats:p>","DOI":"10.1111\/j.1751-0813.2012.00947.x","type":"journal-article","created":{"date-parts":[[2012,6,26]],"date-time":"2012-06-26T13:01:35Z","timestamp":1340715695000},"page":"272-274","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Motor neurone disease in molybdenum\u2010deficient sheep fed the endogenous purine xanthosine: possible mechanism for <i>Tribulus<\/i> staggers"],"prefix":"10.1111","volume":"90","author":[{"given":"CA","family":"Bourke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2006.tb13128.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)30805-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1984.tb07156.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(97)01086-8"},{"key":"e_1_2_7_6_2","first-page":"303","volume-title":"Basic neurochemistry: molecular, cellular and medical aspects","author":"Linden J","year":"2006"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000314841"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19900097"},{"key":"e_1_2_7_10_2","first-page":"633","article-title":"Purine metabolite concentrations in portal and peripheral blood of steers, sheep and rats","volume":"101","author":"Balcells J","year":"1992","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_7_11_2","volume-title":"Xanthine oxidoreductase: role in human pathophysiology and in hereditary xanthinuria","author":"Raivio K","year":"2001"},{"key":"e_1_2_7_12_2","volume-title":"Estimation of microbial protein supply to sheep and cattle based on urinary excretion of purine derivatives","author":"Chen XB","year":"1995"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0970318"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03006-7"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(90)90021-R"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/59.4.539"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0021-9258(19)43008-1","article-title":"Molecular basis of the biological function of molybdenum: effect of tungsten on xanthine oxidase and sulphite oxidase in the rat","volume":"249","author":"Johnson JL","year":"1974","journal-title":"J Biol Chem"},{"key":"e_1_2_7_18_2","unstructured":"BourkeCA.Some taxonomic agronomic and animal health aspects ofTribulus. 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