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A diagnosis of chronic rhinosinusitis with myxomatous polyps was based on the histology of biopsy samples, so prednisolone treatment was administered for 1 month. Although the clinical signs slightly improved, no changes were observed on the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images. At 8 months after the initial presentation, the dog was treated with antivascular photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) using benzoporphyrin derivative monoacid ring A and, 11 days later, <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> revealed remarkably decreased soft tissue opacity; the facial swelling and sneezing also resolved. Three additional sessions of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> were performed at 114, 210, and 303 days after the first <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> because of recurrence of clinical signs. 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