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Our studies aimed at defining the pathophysiological function of MIF in cutaneous inflammatory reactions and in the development and progression of NMSC. Immunohistochemical analysis revealed a moderate expression of MIF in normal human skin samples but an enhanced expression of this cytokine in lesional skin of patients with actinic keratosis or cutaneous SCC. Enzyme\u2010linked immunosorbent assay studies showed a time\u2010dependent increase in MIF secretion after a moderate single\u2010dose UVB irradiation in NHEKs and SCC tumor cells. MIF is known to interact with CXCR2, CXCR4 and CD74. These receptors are not constitutively expressed in keratinocytes and HaCaT cells and their expression is not induced by UVB irradiation either. However, stimulation with IFN\u03b3 upregulated CD74 surface expression in these cells. Affymetrix<jats:sup>\u00ae<\/jats:sup> Gene Chip analysis revealed that only keratinocytes prestimulated with IFN\u03b3 are responsive to MIF. These findings indicate that MIF may be an important factor in the pathogenesis of NMSC <jats:styled-content>tumorigenesis<\/jats:styled-content> and progression in an inflammatory environment.<\/jats:p>","DOI":"10.1111\/j.1751-1097.2012.01108.x","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T15:20:34Z","timestamp":1328973634000},"page":"1157-1164","source":"Crossref","is-referenced-by-count":19,"title":["Expression and Function of Macrophage Migration Inhibitory Factor in the Pathogenesis of UV\u2010Induced Cutaneous Nonmelanoma Skin Cancer<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"88","author":[{"given":"Ruth","family":"Heise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Vetter\u2010Kauczok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Skazik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Czaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Lue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans F.","family":"Merk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Bernhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens M.","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01027.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00782.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10487.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00156.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.021"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1200"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2029"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1567"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.729125"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.071"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01194.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-119628"},{"key":"e_1_2_6_14_2","first-page":"345","article-title":"Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours","volume":"28","author":"Miracco C.","year":"2006","journal-title":"Int. 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