{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:01:33Z","timestamp":1788267693348,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the effects of low\u2010level laser therapy (<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>) in the liver function, structure and inflammation in a experimental model of carbon tetrachloride (<jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub>)\u2010induced liver cirrhosis. Wistar rats were divided into Control, <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub> and <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub>+<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> groups. <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub> groups received <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub> (0.4\u00a0g\u00a0kg<jats:sup>\u22121<\/jats:sup>; i.p.), three times a week, for 12\u00a0weeks. A 830\u00a0nm <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> was performed with a continuous wave, 35\u00a0mW, 2.5\u00a0J\u00a0cm<jats:sup>\u22122<\/jats:sup> per point, applied to four points of the liver (right and left upper and lower extremities, in the four lobes of the liver) for 2\u00a0weeks. Liver structure and inflammation (cirrhotic areas, collagen deposition, inflammation, density of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>upffer and hepatic stellate cells) and function (aspartate aminotransferase, alkaline phosphatase, gamma glutamyltransferase, lactate dehydrogenase, total proteins and globulins) were evaluated. LLLT significantly reduced <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub>\u2010increased aspartate aminotransferase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), alkaline phosphatase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), gamma\u2010glutamyl transferase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and lactate dehydrogenase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) activity, as well as total proteins (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and globulins (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> also reduced the number of cirrhotic areas, the collagen accumulation and the hepatic inflammatory infiltrate. Of note, <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> reduced <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub>\u2010increased number of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>upffer cells (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and hepatic stellate cells (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). We conclude that <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> presents beneficial effects on liver function and structure in an experimental model of <jats:styled-content style=\"fixed-case\"><jats:roman>CCl<\/jats:roman><\/jats:styled-content><jats:sub>4<\/jats:sub>\u2010induced cirrhosis.<\/jats:p>","DOI":"10.1111\/j.1751-1097.2012.01211.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T04:30:34Z","timestamp":1343190634000},"page":"173-178","source":"Crossref","is-referenced-by-count":13,"title":["Low\u2010level Laser Therapy Ameliorates <scp>CC<\/scp>l<sub>4<\/sub>\u2010induced Liver Cirrhosis in Rats"],"prefix":"10.1111","volume":"89","author":[{"given":"Manoel Carneiro","family":"Oliveira\u2010Junior","sequence":"first","affiliation":[{"name":"Post\u2010graduation Program in Biophotonics Applied to Health Sciences Nove de Julho University S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda\u00edza Salom\u00e3o","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Pharmacodynamics Institute of Research and Development University of Vale do Para\u00edba S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto C\u00e9sar Pinto","family":"Leal\u2010Junior","sequence":"additional","affiliation":[{"name":"Post\u2010graduation Program in Biophotonics Applied to Health Sciences Nove de Julho University S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egberto","family":"Munin","sequence":"additional","affiliation":[{"name":"N\u00facleo do Parque Tecnol\u00f3gico de S\u00e3o Jos\u00e9 dos Campos University Camilo Castelo Branco S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Al\u00e9xis Lazo","family":"Os\u00f3rio","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Pharmacodynamics Institute of Research and Development University of Vale do Para\u00edba S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and Pharmacodynamics Institute of Research and Development University of Vale do Para\u00edba S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Paula","family":"Vieira","sequence":"additional","affiliation":[{"name":"Post\u2010graduation Program in Biophotonics Applied to Health Sciences Nove de Julho University S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2838"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025138"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.86"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.123"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02185.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2009.2756"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1089"},{"key":"e_1_2_6_9_1","first-page":"192","article-title":"The effect of low\u2010energy He\u2010Ne laser irradiation on liver regeneration","volume":"3","author":"Silva Junior O. C.","year":"1991","journal-title":"Res. Surg."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0991-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0938-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502006000700007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.892"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181666f1c"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/648915"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1970.19.1.54"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33367"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33023"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23785"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80006-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.04.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.alc.0000189288.30358.4b"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i12.1753"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20383"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2879"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/868345"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i20.2543"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660406"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700203"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.892"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21053"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20101097.2012.01179.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(90)90041-H"},{"key":"e_1_2_6_35_1","first-page":"1029","article-title":"Diagnostic evaluation of carbon tetrachloride\u2010induced rat hepatic cirrhosis model","volume":"25","author":"Lee G. P.","year":"2005","journal-title":"Anticancer Res."},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10141"},{"issue":"2","key":"e_1_2_6_37_1","first-page":"97","article-title":"Efeitos do laser na fun\u00e7\u00e3o mitocondrial e regenera\u00e7\u00e3o hep\u00e1tica em ratos cirr\u00f3ticos hepatectomizados","volume":"15","author":"Lima A. A. L. A.","year":"2009","journal-title":"Acta Cir. Br\u00e1s."},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502002000900019"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0955-5"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20225"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20910"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1751-1097.2012.01211.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1751-1097.2012.01211.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T15:18:29Z","timestamp":1696691909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1751-1097.2012.01211.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,18]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1751-1097.2012.01211.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1751-1097.2012.01211.x","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,18]]}}}