{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T14:33:33Z","timestamp":1721572413249},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,25]],"date-time":"2011-07-25T00:00:00Z","timestamp":1311552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:\u2003<\/jats:bold> The aim was to evaluate the interleukin (IL)\u201027 levels in <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>)\u2010infected patients with gastric ulcer (GU) or duodenal ulcer (DU) and to determine its association with <jats:italic>H. pylori<\/jats:italic> virulence factor cytotoxin\u2010associated gene A (CagA).<\/jats:p><jats:p><jats:bold>METHODS:\u2003<\/jats:bold> In all, 127 <jats:italic>H. pylori<\/jats:italic> infected patients (including 96 DU patients, of whom 61 were anti\u2010CagA<jats:sup>+<\/jats:sup> and 35 were anti\u2010CagA<jats:sup>\u2010<\/jats:sup>) and 31 GU patients (of whom 15 were anti\u2010CagA<jats:sup>+<\/jats:sup> and 16 were anti\u2010CagA<jats:sup>\u2010<\/jats:sup>), 60 asymptomatic (AS) carriers (of whom 30 were anti\u2010CagA<jats:sup>+<\/jats:sup> and 30 were anti\u2010CagA<jats:sup>\u2010<\/jats:sup>) and 30 healthy <jats:italic>H. pylori<\/jats:italic>\u2010negative participants (as a control) were enrolled in the study. Serum concentrations of IL\u201027 were measured by the enzyme\u2010linked immunosorbent assay method.<\/jats:p><jats:p><jats:bold>RESULTS:\u2003<\/jats:bold> The mean levels of IL\u201027 in the GU (44.26\u2003\u00b1\u20037.12\u2003pg\/mL) and DU patients (40.84\u2003\u00b1\u20033.90\u2003pg\/mL) was significantly higher than those observed in the AS carriers (22.06\u2003\u00b1\u20031.90\u2003pg\/mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and the control group (18.12\u2003\u00b1\u20031.68\u2003pg\/mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.002, respectively). In the GU, DU and AS groups the levels of IL\u201027 in anti\u2010CagA<jats:sup>+<\/jats:sup> participants were not significantly differ from that in the anti\u2010CagA<jats:sup>\u2010<\/jats:sup> participants.<\/jats:p><jats:p><jats:bold>CONCLUSIONS:\u2003<\/jats:bold> These results showed that the mean concentration of IL\u201027 in <jats:italic>H. pylori<\/jats:italic>\u2010infected peptic ulcer (PU) patients was higher than in AS carriers and the healthy control group. The serum concentrations of IL\u201027 were not affected by the CagA factor.<\/jats:p>","DOI":"10.1111\/j.1751-2980.2011.00510.x","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T11:24:07Z","timestamp":1305717847000},"page":"302-307","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Circulating interleukin\u201027 levels in <i>Helicobacter pylori<\/i>\u2010infected patients with gastric or duodenal ulcers, independent of the bacterial cytotoxin\u2010associated gene A virulence 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