{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:59:54Z","timestamp":1792479594792,"version":"4.5.0"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T00:00:00Z","timestamp":1324425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Extramedullary plasmacytoma (EMP) of the small intestine is an unusual plasma cell neoplasm in this anatomic region with only 61 cases described so far. Clinical suspicion is infrequent owing to its location and nonspecific manifestations such as abdominal pain, obstructive symptoms or even bleeding. Diagnosis is reached through histopathological examination coupled with immunohistochemistry of the endoscopic biopsy or surgical resection specimens. Nevertheless, the differential diagnosis between EMP, lymphoma and other kinds of tumors can sometimes be troublesome. The managements include surgery, radiotherapy or chemotherapy. Generally, the prognosis of EMP is favorable, but occasionally it may relapse, or progress to a plasma cell myeloma. EMP should therefore be followed\u2010up for a long period after treatment. In this comprehensive review of the current literature, the patients' characteristics, clinical manifestations, diagnosis, differential diagnosis, treatment and outcome were discussed.<\/jats:p>","DOI":"10.1111\/j.1751-2980.2011.00544.x","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T12:50:34Z","timestamp":1319028634000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Extramedullary plasmacytoma of the small intestine: Clinical features, diagnosis and treatment"],"prefix":"10.1111","volume":"13","author":[{"given":"Rodrigo","family":"LOPES DA SILVA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2005.05.001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2305::AID-CNCR2>3.0.CO;2-3"},{"key":"e_1_2_5_4_2","first-page":"101","article-title":"Radiotherapy in the management of plasma cell tumors","volume":"14","author":"Hu K","year":"2000","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(47)91368-8"},{"key":"e_1_2_5_6_2","first-page":"441","article-title":"Extramedullary plasmacytoma of the duodenum","volume":"106","author":"Haraszti A","year":"1964","journal-title":"Zentralbl Allg Pathol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1229861"},{"key":"e_1_2_5_8_2","first-page":"3278","article-title":"Primary duodenal plasmacytoma: an autopsy case","volume":"36","author":"Hirakawa T","year":"1978","journal-title":"Jpn J Clin Med"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207649"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1979.tb05878.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb02356.x"},{"key":"e_1_2_5_12_2","first-page":"77","article-title":"Obstructing plasmacytoma of the duodenum: first manifestation of relapsed multiple myeloma","volume":"83","author":"Gradishar W","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.823.378"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01166.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1024\/1023-9332.5.1.6"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.117962"},{"key":"e_1_2_5_17_2","first-page":"1729","article-title":"Plasmacytoma and AIDS: unusual duodenal localization","volume":"82","author":"Juglard R","year":"2001","journal-title":"J Radiol"},{"key":"e_1_2_5_18_2","first-page":"147","article-title":"A case of duodenal involvement of multiple myeloma imaged by positron emission tomography with 18F\u2010fluorodeoxyglucose","volume":"26","author":"Yasuda S","year":"2001","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10468"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.08.015"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0719"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3565"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.03.005"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181bf66a2"},{"key":"e_1_2_5_25_2","first-page":"1919","article-title":"Plasmacytoma of the small intestine","volume":"35","author":"Bastrup\u2010Madsen P","year":"1947","journal-title":"Nord Med"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(54)80075-8"},{"key":"e_1_2_5_27_2","first-page":"423","article-title":"Plasmacytoma of the gastrointestinal tract","volume":"39","author":"Vedachalam SP","year":"1962","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_5_28_2","first-page":"347","article-title":"Plasmacytoma of the small intestine","volume":"40","author":"Bednarek TH","year":"1968","journal-title":"Pol Przegl Chir"},{"key":"e_1_2_5_29_2","first-page":"57","article-title":"Solitary plasmacytoma of the jejunum","volume":"98","author":"Jaeger M","year":"1968","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_5_30_2","first-page":"306","article-title":"Isolated plasmacytoma located in the jejunum\u2010ileum","volume":"98","author":"Daiber A","year":"1970","journal-title":"Rev Med Chil"},{"key":"e_1_2_5_31_2","first-page":"270","article-title":"Plasmacytoma of the small intestine. 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